RDRP_BYDV1
ID RDRP_BYDV1 Reviewed; 867 AA.
AC P29044;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 29-SEP-2021, entry version 82.
DE RecName: Full=Putative RNA-directed RNA polymerase;
DE EC=2.7.7.48;
GN ORFNames=ORF1/ORF2;
OS Barley yellow dwarf virus (isolate MAV-PS1) (BYDV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC Tolivirales; Tombusviridae; Luteovirus.
OX NCBI_TaxID=31723;
OH NCBI_TaxID=146531; Avena byzantina.
OH NCBI_TaxID=4498; Avena sativa (Oat).
OH NCBI_TaxID=4513; Hordeum vulgare (Barley).
OH NCBI_TaxID=4521; Lolium multiflorum (Italian ryegrass) (Lolium perenne subsp. multiflorum).
OH NCBI_TaxID=4522; Lolium perenne (Perennial ryegrass).
OH NCBI_TaxID=4530; Oryza sativa (Rice).
OH NCBI_TaxID=4550; Secale cereale (Rye).
OH NCBI_TaxID=4565; Triticum aestivum (Wheat).
OH NCBI_TaxID=4577; Zea mays (Maize).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1538199; DOI=10.1099/0022-1317-73-2-487;
RA Ueng P.P., Vincent J.R., Kawata E.E., Lei C.H., Lister R.M., Larkins B.A.;
RT "Nucleotide sequence analysis of the genomes of the MAV-PS1 and P-PAV
RT isolates of barley yellow dwarf virus.";
RL J. Gen. Virol. 73:487-492(1992).
CC -!- FUNCTION: Probable polymerase.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Ribosomal frameshifting; Named isoforms=2;
CC Name=Putative RNA-directed RNA polymerase;
CC IsoId=P29044-1; Sequence=Displayed;
CC Name=39 kDa protein;
CC IsoId=P29044-2; Sequence=VSP_031894;
CC -!- MISCELLANEOUS: [Isoform Putative RNA-directed RNA polymerase]: Produced
CC by -1 ribosomal frameshifting between codons 339 and 340.
CC -!- MISCELLANEOUS: [Isoform 39 kDa protein]: Produced by conventional
CC translation. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the luteoviruses RNA polymerase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D11028; BAA01779.1; ALT_FRAME; Genomic_RNA.
DR PIR; JQ1409; RRVQBM.
DR PRIDE; P29044; -.
DR Proteomes; UP000203063; Genome.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR013674; Luteo_Rpol_P1-P2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR002166; RNA_pol_HCV.
DR Pfam; PF08467; Luteo_P1-P2; 1.
DR Pfam; PF00998; RdRP_3; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW Ribosomal frameshifting; RNA-directed RNA polymerase; Transferase;
KW Viral RNA replication.
FT CHAIN 1..867
FT /note="Putative RNA-directed RNA polymerase"
FT /id="PRO_0000039184"
FT DOMAIN 561..676
FT /note="RdRp catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
FT VAR_SEQ 340..867
FT /note="Missing (in isoform 39 kDa protein)"
FT /evidence="ECO:0000305"
FT /id="VSP_031894"
SQ SEQUENCE 867 AA; 98893 MW; DF5A6E944488D8D2 CRC64;
MFFEILIGAS TKAVKDFISH CYSRLKSIYY CFKRWLMEIS GQFKAHDAFV NMCFGHMADI
EDFEAELAEE FAEREDEVEE ARSLLKLLVA QKSKTGVTEA WTDFFTKSRG GVYAPLSCEP
TRQDLEVKSE KLEKLLEEQH QFEVRAAKKY IKEKGRGFIN CWNDLRSRLR LVKDVKDEAK
DNARAAAKIG AEMFAPVDVQ DLYSFTEVKK VETGLMKEVV KERNGEEEKH LEPIMEEVRS
IKDTAEARDA ASTWITETIK LKNSTLNADE LSLATIARYV ENVGDKFKLD IASKTYLKQV
ASMSVPIPTN KDIKLKMVLQ SPEARARRER MDVLDSVGFL EGLCTASGFE SPFPILGLPE
IAVTDGARLR KVSCNIRYLS QTHLGLVYKA PNASLHNALV AVERRVYTVG KGDKAIYPPR
PEHDIFTDTM DYFQKSIIEE VGYCKTYPAQ LLANSYSAGK RAMYHKAIAS LRTIPYHQKD
ANVQAFLKKE KHWMTKDIAP RLICPRSKRY NIILGTRLKF NEKKIMHAID SVFGSPTVLS
GYDNFKQGRI IAKKWQKFAC PVAIGVDASR FDQHVSEQAL KWEHGIYNGV FGDSELALAL
EHQITNNIKM FVEDKMLRFK VRGHRMSGDI NTSMGNKLIM CGMMHAYFKK LGVEAELCNN
GDDCVIITDR ANEKLFDGMY DHFLRYGFNM VTEKPVYELE QLEFCQSKPV SINGKYRMVR
RPDSIGKDST TLLSMLNQSD VKSYMSAVAQ CGLVLNAGVP ILESFYKCLY RSSGYKKVSE
EFIKNVISYG TDERLQGRRT FQDTPITNHS RMSYWESFGV DPKIQQIVER YYDNLTVSAQ
LQSVKVTTPH LQSILLSIPE NHSHNEY