ID   RDRP_CGMVW              Reviewed;         153 AA.
AC   P69515; P19523; P89877; P90356; Q83208;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   23-FEB-2022, entry version 43.
DE   RecName: Full=Replicase large subunit;
DE            EC=2.7.7.48;
DE   AltName: Full=183 kDa protein;
DE   Flags: Fragment;
OS   Cucumber green mottle mosaic virus (strain watermelon W) (CGMMV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Tobamovirus.
OX   NCBI_TaxID=12237;
OH   NCBI_TaxID=3653; Citrullus.
OH   NCBI_TaxID=3659; Cucumis sativus (Cucumber).
OH   NCBI_TaxID=3668; Lagenaria siceraria (Bottle gourd) (Lagenaria leucantha).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3201760; DOI=10.1016/s0042-6822(88)90132-8;
RA   Saito T., Imai Y., Meshi T., Okada Y.;
RT   "Interviral homologies of the 30K proteins of tobamoviruses.";
RL   Virology 167:653-656(1988).
CC   -!- FUNCTION: The replicase large subunit is an RNA-dependent RNA
CC       polymerase active in viral RNA replication. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
CC   -!- SIMILARITY: Belongs to the tobamovirus RNA-directed RNA polymerase
CC       family. {ECO:0000305}.
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DR   EMBL; J04322; AAA46382.1; -; Genomic_RNA.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001788; Tymovirus_RNA-dep_RNA_pol.
DR   Pfam; PF00978; RdRP_2; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase.
FT   CHAIN           <1..153
FT                   /note="Replicase large subunit"
FT                   /id="PRO_0000144975"
FT   NON_TER         1
SQ   SEQUENCE   153 AA;  17399 MW;  A8C381CA95D4A48E CRC64;
     ASMLPLDKCF KASFCGDDSL IYLPKGLEYP DIQATANLVW NFEAKLFRKK YGYFCGKYII
     HHANGCIVYP DPLKLISKLG NKSLVGYEHV EEFRISLLDV AHSLFNGAYF HLLDDAIHEL
     FPNAGGCSFV INCLCKYLSD KRLFRSLYID VSK