ID   RDRP_CPVKS              Reviewed;         524 AA.
AC   O15925;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   23-FEB-2022, entry version 72.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            EC=2.7.7.48;
OS   Cryptosporidium parvum virus 1 (strain KSU-1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Duplopiviricetes;
OC   Durnavirales; Partitiviridae; Cryspovirus.
OX   NCBI_TaxID=766191;
OH   NCBI_TaxID=5807; Cryptosporidium parvum.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9383154; DOI=10.1046/j.1365-2958.1997.5721933.x;
RA   Khramtsov N.V., Woods K.M., Nesterenko M.V., Dykstra C.C., Upton S.J.;
RT   "Virus-like, double-stranded RNAs in the parasitic protozoan
RT   Cryptosporidium parvum.";
RL   Mol. Microbiol. 26:289-300(1997).
CC   -!- FUNCTION: RNA-dependent RNA polymerase which replicates the viral
CC       genome. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
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DR   EMBL; U95995; AAC47805.1; -; Genomic_RNA.
DR   SMR; O15925; -.
DR   Proteomes; UP000006921; Genome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE   4: Predicted;
KW   Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW   RNA-directed RNA polymerase; Transferase; Viral RNA replication.
FT   CHAIN           1..524
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000402796"
FT   DOMAIN          220..340
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ   SEQUENCE   524 AA;  61916 MW;  84C8B7AAB4E7FA74 CRC64;
     MKFVNIYEIQ RFDGQPTRHG IAPKKIFRSK YIPTGLVPRL KYWRDVPSRA EMSKRIGKYF
     EDEFKFYPNE EKLNEAVNIV QEKWISHYGT SLNVTSVSES FRTLPKSTSA GLPFKSGCTK
     YEARNKMMRF ARSQWDRVSK ELQLQVLPCR LGARCQLRKR GENKPRLIWA YPGYLSIIEN
     QYLTAIKKVP PPNFIGWSTN WLDGGKSLNR LLFGDKWTWQ SIAQIDFSSF DATVRTELIF
     HAFKILRSLF DLTRTENIML DQLRHYFINT PILFYDKIIV KNRGIPSGSA FTQIIGTIVN
     MIACQYASLR SRDYNLRIPF SCWLGDDSFL NFETALCRQE FEYDYLEKFK ELGLNVSIDK
     THYTTRFIDD FEVRFKGVRP YVKFLGKQID ILLDLTFHND LDKLDAQMAL PEKEDLSAYE
     TGVRLIGLVW AYGAHYDIYL RILKVYLSLK LKPEFHVQQL LSYSEKPERT KRYQENFFSS
     MKYQLNLDLD IYDLLAFPKF WDVSNRYFGS KYERLDFRSH KIYG