ID   RDRP_DHVI1              Reviewed;         716 AA.
AC   P27153;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   23-FEB-2022, entry version 65.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit;
DE            EC=2.7.7.48;
DE   AltName: Full=RNA-directed RNA polymerase subunit P2;
GN   Name=P2;
OS   Dhori virus (strain Indian/1313/61) (Dho).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Thogotovirus.
OX   NCBI_TaxID=11319;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=6935; Ixodida (ticks).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2024457; DOI=10.1016/0042-6822(91)90641-n;
RA   Lin D.A., Roychoudhury S., Palese P., Clay W.C., Fuller F.J.;
RT   "Evolutionary relatedness of the predicted gene product of RNA segment 2 of
RT   the tick-borne Dhori virus and the PB1 polymerase gene of influenza
RT   viruses.";
RL   Virology 182:1-7(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SUBUNIT: RNA polymerase is composed of three subunits: PA, PB1 and PB2.
CC   -!- SIMILARITY: Belongs to the influenza viruses polymerase PB1 family.
CC       {ECO:0000305}.
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DR   EMBL; M65866; AAA42968.1; -; Genomic_RNA.
DR   PIR; A39145; P1IVDV.
DR   SMR; P27153; -.
DR   PRIDE; P27153; -.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding; Nucleotidyltransferase; RNA-directed RNA polymerase;
KW   Transferase; Viral RNA replication.
FT   CHAIN           1..716
FT                   /note="RNA-directed RNA polymerase catalytic subunit"
FT                   /id="PRO_0000078777"
FT   DOMAIN          286..465
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ   SEQUENCE   716 AA;  81292 MW;  F5B0DCE590350B2A CRC64;
     MNLFSPRTGL SPTETQELLY AYTGPAPVAY GTRTRAVLEN VLRPYKYFYK EENVPQALHI
     KTGQKGPEEI STTSPSSGFH RDSVILLSRE LKAKYPEAFE RLKAWIDCEL LEMEYAELSK
     GRQTLSFLRN RNQPAPIALE ETIEYLQQNL GRPIGQSMLS YLRAVMEVLA MPKTTFTYEV
     ATNLARFDFE EYDDGETGPL MMHFEKEKKK ITITITQAEL WEKTCTLGTM WKHLERGRLN
     RRTIATPSML ARGFVKIVED AARVLLECLP SSGVPVGGEE KLAKLSSKLE AVSEVTGELS
     GDQEKFNECL DPDAMRLMWT VFLEDYPQWV KELFNIPFLI FKAKIADIGE GLTYQKEGVV
     RVFPFGEMPS EFDELLPNAI KDKEGKIVGI RCTLGMFMGM FNLSSTLLAL IAADRSEITG
     DHVESSDDFI HFFKAKSYDD MFKQAELLRW SLKLVGINMS PSKCILISPA GIGEFNSKYH
     HRDFVGNVAT DLPSLVPGGK NPSSDLAMGL NVIRHSINTN QMNFISGDLA LRIFTKAYRH
     SYMAEGITRR TKFLEAFKKD PVLLNQGAPT VHSVSTLHLD EVCLRYQMHL LGEEELRRIM
     NPSNPITART EEVVSFRPEG KLPMILEDNS VGSCFKYTFT RNRTVTDKPH RVLLEKEQQY
     QKITSFVEEC FPELTIGNTT MPGTVKQACK RRLEYIIEQS DLPTEQKRAL LEEMDS