ID   RDRP_ESRV9              Reviewed;        1217 AA.
AC   Q698V5;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   29-SEP-2021, entry version 36.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            EC=2.7.7.48;
OS   Eriocheir sinensis reovirus (isolate China/905) (EsRV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Cardoreovirus.
OX   NCBI_TaxID=648171;
OH   NCBI_TaxID=95602; Eriocheir sinensis (Chinese mitten crab).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Zhang S.;
RT   "Sequence of segment 1 of crustacean reovirus 905 isolated from Chinese
RT   mitten-handed crab (Eriocheir sinensis).";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-directed RNA polymerase that is involved in transcription
CC       and genome replication. Following infection, it catalyzes the synthesis
CC       of fully conservative plus strands. After core assembly, which consists
CC       in recruitment of one capped plus-strand for each genomic segments and
CC       polymerase complexes, the polymerase switches mode and catalyzes the
CC       synthesis of complementary minus-strands (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the reoviridae RNA-directed RNA polymerase
CC       family. {ECO:0000305}.
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DR   EMBL; AY542965; AAT11887.1; -; Genomic_RNA.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR026381; Seadorna_RNAP.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   TIGRFAMs; TIGR04234; seadorna_RNAP; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Nucleotide-binding; Nucleotidyltransferase;
KW   RNA-directed RNA polymerase; Transferase; Viral RNA replication; Virion.
FT   CHAIN           1..1217
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000404333"
SQ   SEQUENCE   1217 AA;  138371 MW;  A747B20574091130 CRC64;
     MDTYGSIKRD LKYMYDVEEV FRNTIPKTYF GIDDVEDLHV DEAGISNIHN NITLGTKKCY
     HLYKKGHRTQ VPIYLGSLVT RESNEYEDVS YSYDNLNTIY KDAPVWEPLL NKVSKWYDEG
     WSVPSSKPIP YDPNYSKCLI LSPDKYKKYH KVVVDVDYDA FHWSIDVNSE FMDMPNVIRA
     WDISTIPQFV DGFPMLKHLI DRSKKEALFY FNYRLIPYVV HNIDKDDDMW REWLSYFLHG
     DHFKPDRGSY DNFGSLLGHK RLEVALMYHN RIRLMPMSAT ALDAMNEGAK FLMKDPTYHT
     AVMKKYNGVL TQYGMAEPLG YNRGWGYTGV TTADSPFILS NVNGADGYTV IDREAVEEAK
     EIGMQYTPKL VKLQLANMTK TSSPVNLIDS LIGNAIISLT GFAGSEKVST ALDQFEKENF
     ERKVPDELFT AISNVTYEMV RESFQPLERS MLDKRTRLLR LYNAGTSASS SAPPGARYIF
     NKKMIMYSTF LSKSIDVTDE YAPMSFITSL NFNNKTANIL THPQNYYMYD WHDNHNRIIN
     SGSREVRGGR ATRIITPDPP SNYMLLILGA LNTVRDMGSH RTGFSNLGMN EVVGSSFLDA
     VSHDALAPQC LATSSSRSLC AQALDYSTWD RQQGGRIAEA KAHGIMRVAN ELFPNTNTNL
     SDVHNLLELP MSSILYLWSE SIKSSYKYKI DHSTVAVDAV RSGELTTQFS NHVTNLAALR
     QYHETYNRTK VPQGFRPIEV AQINIVGDDV NVILRTADRK PFTLRDMEGY HNHTFEKAAE
     YEFSISKKRS MMSNVATEHI KQYFKMGDIL LDVMLSSMTS ERNTFREQGY MNGINLLYDI
     AVTIMARYAQ NDKLFEDMMA NLPFMEGVVY RHGSQKYHFH PSPCHLLGSG SPEILPSAID
     LRTFARVITV LGDYESDLYE AMSSLNATLL STSGTTQFES QVRKHLSEEL GDNIISPVWS
     EVFYRDEVGY EMVTKHNKLT PEGHREYLVD RIISTLSNRE KLIMNNADII EKLLSGKLKK
     VKRYFQEIKF KMSNMPITGL PDRKIEGVSE LSSPYRAADV GMRRVHKCIG LSRRNLKFPS
     VTERLSRLLK SYGLVTQADS AKILSAAAGL GRSSTRYRNL GTDLGLSDMH ASSFAQRLPA
     LLTQYEIENA SGSFTFYDTV SRTYDVSEAS MNERVGDVSN NPIARANSST STYYRFRGML
     HCLYGARFGL SLHASVE