ID   RDRP_FDVS               Reviewed;        1470 AA.
AC   Q8JYK1;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   29-SEP-2021, entry version 49.
DE   RecName: Full=RNA-directed RNA polymerase VP1;
DE            EC=2.7.7.48;
GN   Name=S1;
OS   Fiji disease virus (isolate Sugarcane) (FDV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Fijivirus.
OX   NCBI_TaxID=648172;
OH   NCBI_TaxID=4547; Saccharum officinarum (Sugarcane).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12876456; DOI=10.1023/a:1024403431373;
RA   McQualter R.B., Smith G.R., Dale J.L., Harding R.M.;
RT   "Molecular analysis of Fiji disease Fijivirus genome segments 1 and 3.";
RL   Virus Genes 26:283-289(2003).
CC   -!- FUNCTION: RNA-directed RNA polymerase that is involved in transcription
CC       and genome replication. Following infection, it catalyzes the synthesis
CC       of fully conservative plus strands. After core assembly, which consists
CC       in recruitment of one capped plus-strand for each genomic segments and
CC       polymerase complexes, the polymerase switches mode and catalyzes the
CC       synthesis of complementary minus-strands (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
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DR   EMBL; AY029520; AAK40249.1; -; Genomic_RNA.
DR   RefSeq; YP_249762.1; NC_007159.1.
DR   GeneID; 5075882; -.
DR   KEGG; vg:5075882; -.
DR   Proteomes; UP000001677; Genome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Hydrolase; Nucleotidyltransferase; Reference proteome;
KW   RNA-directed RNA polymerase; Transferase; Viral RNA replication.
FT   CHAIN           1..1470
FT                   /note="RNA-directed RNA polymerase VP1"
FT                   /id="PRO_0000403405"
FT   REGION          28..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1470 AA;  170645 MW;  34D75415E3ABA02D CRC64;
     MIVRTVCRAK EKCLEKYKNI LKYKEQLAKQ DQKENETTSN NKDTSSSVPK PSNFRKTKVQ
     NQYNRVFSID EKVAEYEKIL NDKVNMIDAI FNKAEKIRDL FIGTEPLTKE LIKNELQYGA
     IVLNRASDLI LAFADNNEPR EPEFVLNTDM IVNDLKPLLH PTRIFDYSSF GFDDVNKLAI
     NPKIRYLPNW SINYIRKCIQ SFFTSNSNIE VQNLHNYSNH YDNRIYEHAM PNDVKLQILI
     GLDKMFNKLS IQHRFGTFET QILSCFFMKQ KICEYEAYMH LPDCVNKSKK LKKGTETVCW
     QYLAEIIKHY EGIPFYHHTH SSKFGALDNT KISITTNKEV SCCLPSVMHG LLNGIIGELL
     CDLSTETALI YAKHLMNCSA TSTYQRQLEF KDSFRMWPKL CYDSIGYALA VLYSKDMKPL
     EHRVEKIDSE FWFDEEEKDK LSSSLSKIPS YMKPFVNNAI QNCKKRGDYI NQMICDINKI
     KLSREPNKFE THDLYLESGK NTEYLRWLTM TSTIISNFGI YNKTSLLLEY EKSISTKTKV
     MVQQPEPKVS LITEQGLQTP ILHDWTKVPV LNEMSSLFDS EWKSTLVKEF EDINDFEKRF
     VTFLTNKSGG IKSEEPTLSK ELKGISNARI IAFALNRNDY QIESKFLNML IAHGKCAIRF
     QIDRRARVIV IVPNAIQSSE LFLLLGFNVL KSDKRFNEKI AVGKQIGNLL DAKAQMISSG
     DVLSVKNSSD MKGMDAHTLP NLTLFLRRKM IEVLYELDPT GKCARYFFAE DKEYCLIQHH
     EKYHEQFVRR LRGPTIHAAK CLYYMFSMNM YLEDNFFSKG MNVSDQTFQS GFFATSAQHT
     LFLSLYLLNN ERKYFSKLDN RMIRLLHSVM GDDVFEVIVN GVKYPNLVKE WLKLRNQGLS
     KINYEEDVSL SRLFGVFLQQ AAILGVYVPY PARMSLFCDE RSDTTKRHTL DMIKIVLEVL
     SSKSQRSYAI DNNISIGYAI WNCHRTSRYL YTDRDKSLIR RLVDHDANLD KLFVIDLSKF
     ENSVRLVYPF VTIMTSPISW PMLYFAHFKI DDPNCTILTY RAKSPTSLNG DGAFLLINQM
     FFTSDEEHMF KFVEFVKHQD KVVRLKLSSD FLDWKERHTW GFTLGEHLLR FKRLRHLTES
     RKSELGLGEI EVMVHNLNKY LDSHRVQMSL DSFDQLRKNK ITVPSSLMYV NHNRAKIEQS
     LTVRTETLDE RASLDSTFLR HVFSYSIVPK DIEVLKTHAL CAIKVRTYSD LKYALSVDGY
     LPESDDSSFN VILPFLPGYH QSSSYGRLFR YTTLPTVHDR DISGTMGEIV GGLGASFDID
     SAIEFGAYVY NINRNLINAA ASAIGIPQKF VSKYEQLVQA FIMNNFNLKY HSIFHNAKYF
     GLSGSLKKFS EYGGYSNKLI RFDTINKMEK FHNAFTRDLV FAYIDELNGR RVYLDYSIHS
     LLLIMSRGSI KYFTTHLYKL FNPLLSLELD