ID   RDRP_IBDVA              Reviewed;         878 AA.
AC   P12918;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            Short=RDRP;
DE            EC=2.7.7.48;
DE   AltName: Full=Protein VP1;
GN   Name=VP1;
OS   Avian infectious bursal disease virus (strain Australian 002-73) (IBDV)
OS   (Gumboro disease virus).
OC   Viruses; Riboviria; Orthornavirae; Birnaviridae; Avibirnavirus.
OX   NCBI_TaxID=10997;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2831661; DOI=10.1016/0042-6822(88)90258-9;
RA   Morgan M.M., Macreadie I.G., Harley V.R., Hudson P.J., Azad A.A.;
RT   "Sequence of the small double-stranded RNA genomic segment of infectious
RT   bursal disease virus and its deduced 90-kDa product.";
RL   Virology 163:240-242(1988).
CC   -!- FUNCTION: RNA-dependent RNA polymerase which is found both free and
CC       covalently attached to the genomic RNA. May also contain guanylyl and
CC       methyl transferase activities (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SUBUNIT: Interacts with VP3 in the cytoplasm. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Minor amounts are
CC       incorporated in the virion. {ECO:0000250}.
CC   -!- PTM: May exist in multiple phosphorylated forms.
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DR   EMBL; M19336; AAA89177.1; -; Genomic_RNA.
DR   PIR; A28649; RRXSIB.
DR   SMR; P12918; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0018144; P:RNA-protein covalent cross-linking; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR007100; RNA-dir_pol_birnavirus.
DR   InterPro; IPR007098; RNA-dir_pol_mononegavirus.
DR   Pfam; PF04197; Birna_RdRp; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50524; RDRP_DSRNA_BIR; 1.
PE   3: Inferred from homology;
KW   Covalent protein-RNA linkage; GTP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Phosphoprotein; RNA-directed RNA polymerase;
KW   Transferase; Viral RNA replication; Virion.
FT   CHAIN           1..878
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000221962"
FT   DOMAIN          397..597
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
FT   REGION          845..878
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         258..265
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   878 AA;  97274 MW;  6B67C1E0AC193D1F CRC64;
     MSDVFNSPQA RTKISAAFGI KPTAGQDVEE LLIPKVWVPP EDPLASPSRL AKFLRENGYK
     ILQPRSLPEN EEYETDQILP DLAWMRQIEG AVLKPTLSLH WGPRVLPKVL LNSPPEQGKA
     QCVPTRHCTT QADIYLFLQV PEATESLKDE VTLLTQNIRD KAYGSGTYMG QATRLVAMKE
     VATGRNPNKD PLKLGYTFES IAQLLDITLP VGPPGEDDKP WVPLTRVPSR MLVLTGDVDG
     DFEVEDYLPK INLKSSSGLP YVGRTKGETI GEMIAISNQF LRELSALLKQ GAGTKGSNKK
     KLLSMLSDYW YLSCGLLFPK AERYDKSTWL TKTRNIWSAP SPTHLMISMI TWPVMSNSPN
     NVLNIEGCPS LYKFNPFRGG LNRIVEWILA PEEPKALVYA DNIYIVHSNT WYSIDLEKGE
     ANCTRQHMQA AMYYILTRGW SDNGDPMFNQ TWASFAMNIA PALVVDSSCL IMNLQIKSYG
     QGSGNAATFI NNHLLSTLVL DQWNLMKQPN PDSEEFKSIE DKLGINFKIE RSIDDIRGKL
     RQLVPLAQPG YLSGGVEPEQ SSPTVELDLL GWSATYSKDL GIYVPVLDKE RLFCSAAYPK
     GVENKSLKSK VGIEQAYKVV RYEALRLVGG WNYPLLNKAC KNNASAARRH LEAKGFPLDE
     FLAEWSELSE FGETFEGFNI KLTVTRENLA ELNKPVPPKP PNVNRPVNTG GLKAVSNALK
     TGRYRNEAGL SGLVLLATAR SRLQDAVKAK AEAEKLHKSK PDDPDADWFE RSETLSDLLE
     KADVASKVAH SALVETSDAL EAVQSSSVYT PKYPEVKNPQ TASNPVVGLH LPAKRATGVQ
     AALLGAGTSR PMGMEAPTRS KNAVKMAKRA QRQKESRQ