ID   RDRP_IBDVU              Reviewed;         879 AA.
AC   Q82630;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            Short=RDRP;
DE            EC=2.7.7.48;
DE   AltName: Full=Protein VP1;
GN   Name=VP1;
OS   Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989)
OS   (IBDV) (Gumboro disease virus).
OC   Viruses; Riboviria; Orthornavirae; Birnaviridae; Avibirnavirus.
OX   NCBI_TaxID=644440;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8725117; DOI=10.1016/0168-1702(95)01253-2;
RA   Brown M.D., Skinner M.A.;
RT   "Coding sequences of both genome segments of a European 'very virulent'
RT   infectious bursal disease virus.";
RL   Virus Res. 40:1-15(1996).
CC   -!- FUNCTION: RNA-dependent RNA polymerase which is found both free and
CC       covalently attached to the genomic RNA. May also contain guanylyl and
CC       methyl transferase activities (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SUBUNIT: Interacts with VP3 in the cytoplasm. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Minor amounts are
CC       incorporated in the virion. {ECO:0000250}.
CC   -!- PTM: May exist in multiple phosphorylated forms.
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DR   EMBL; X92761; CAA63417.1; -; Genomic_RNA.
DR   RefSeq; NP_690839.1; NC_004179.1.
DR   SMR; Q82630; -.
DR   GeneID; 956510; -.
DR   KEGG; vg:956510; -.
DR   Proteomes; UP000007249; Genome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0018144; P:RNA-protein covalent cross-linking; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR007100; RNA-dir_pol_birnavirus.
DR   InterPro; IPR007098; RNA-dir_pol_mononegavirus.
DR   Pfam; PF04197; Birna_RdRp; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50524; RDRP_DSRNA_BIR; 1.
PE   3: Inferred from homology;
KW   Covalent protein-RNA linkage; GTP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Phosphoprotein; Reference proteome;
KW   RNA-directed RNA polymerase; Transferase; Viral RNA replication; Virion.
FT   CHAIN           1..879
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000378410"
FT   DOMAIN          398..598
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
FT   REGION          847..879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        864..879
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         259..266
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   879 AA;  97691 MW;  4E4BE23D99674DCB CRC64;
     MSDVFNSPQA RSKISAAFGI KPTAGQDVEE LLIPKVWVPP EDPLASPSRL AKFLRENGYK
     ILQPRSLPEN EEYETDQILP DLAWMRQIEG PVLKPTLSLP IGDQEYFPKY YPTHRPSKEK
     PNAYPPDIAL LKQMIYLFLQ VPEATDNLKD EVTLLTQNIR DKAYGSGTYM GQATRLVAMK
     EVATGRNPNK DPLKLGYTFE SIAQLLDITL PVGPPGEDDK PWVPLTRVPS RMLVLTGDVD
     GEFEVEDYLP KINLKSSSGL PYVGRTKGET IGEMIAISNQ FLRELSALLK QGAGTKGSNK
     KKLLSMLSDY WYLSCGLLFP KAERYDKSTC CTKTRNKWSA QSSTHLMISM ITWPVMSNSP
     NNVLNIEGCP SLYKFNPFRG GLNRIVEWIM APDEPKALVY ADNIYIVHSN TWYSIDLEKG
     EANCTRQHMQ AAMYYILTRG WSDNGDPMFN QTWATFAMNI APALVVDSSC LIMNLQIKTY
     GQGSGNAATF INNHLLSTLV LDQWNLMKQP SPDSEEFKSI EDKLGINFKI ERSIDDIRGK
     LRQLVPLAQP GYLSGGVEPE QPSPTVELDL LGWSATYSKD LGIYVPVLDK ERLFCSAAYP
     KGVENKSLKS KVGIEQAYKV VRYEALRLVG GWNYPLLNKA CKNNASAARR HLEAKGFPLD
     EFLAEWSELS EFGEAFEGFN IKLTVTPESL AELNRPVPPK PPNVNRPVNT GGLKAVSNAL
     KTGRYRNEAG LSGLVLLATA RSRLQDAVKA MAEAEKLHKS KPDDPDADWF ERSETLSDLL
     EKADIASKVA HSALVETSDA LEAVQSTSVY TPKYPEVKNP QTASHPVVGL HLPAKRATGV
     QAALLGAGTS RPMGMEAPTR SKNAVKMAKR RQRQKESRQ