ID   RDRP_MRNV               Reviewed;        1045 AA.
AC   Q6XNL5;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   29-SEP-2021, entry version 57.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            Short=RdRp;
DE            EC=2.7.7.48;
DE   AltName: Full=RNA replicase;
OS   Macrobrachium rosenbergii nodavirus (MrNV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Magsaviricetes;
OC   Nodamuvirales; Nodaviridae; unclassified Nodaviridae.
OX   NCBI_TaxID=222557;
OH   NCBI_TaxID=79674; Macrobrachium rosenbergii (Giant fresh water prawn).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bonami J.-R., Sri Widada J., Richard V.R., Vincent A., Durand S.P.;
RT   "Nucleotide sequence of the MrNV-RNA-1 of Macrobrachium rosenbergii.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-dependent RNA polymerase which replicates the viral
CC       genome composed of 2 RNA segments, RNA1 AND RNA2. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
CC   -!- SIMILARITY: Belongs to the nodaviridae RNA polymerase family.
CC       {ECO:0000305}.
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DR   EMBL; AY222839; AAO60068.1; -; Genomic_RNA.
DR   RefSeq; NP_919036.1; NC_005094.1.
DR   GeneID; 2943295; -.
DR   KEGG; vg:2943295; -.
DR   Proteomes; UP000203150; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043647; Noda_Vmethyltr_dom.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   InterPro; IPR020237; Viral_RNA-dir_pol_C.
DR   Pfam; PF19222; Noda_Vmethyltr; 1.
DR   Pfam; PF00680; RdRP_1; 1.
DR   Pfam; PF17501; Viral_RdRp_C; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase;
KW   Viral RNA replication.
FT   CHAIN           1..1045
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000223687"
FT   DOMAIN          593..718
FT                   /note="RdRp catalytic"
FT   REGION          916..1045
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        943..982
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        995..1013
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  118394 MW;  229E7D36C9376032 CRC64;
     MKCNNLLYGV ELPMCLQSSM GMVVVTGLAI VYLVIYILIY SFTHGPRLSR RLASYVVIGP
     YEAIAKSRPA MALQRAMVDL TRRDVRTDWY PLNNLLMNKP HRLSENGHKT SGAVRDAARN
     LITSAITSLG MDKYEISPGG HTVDEQLASH RHYAVNDLHR ASADDAVKEN AVIVAIDTDY
     YLRDPSIYFS NNNPFILHTF QPITVAGKDG DVRFTISDNQ VDYRVDGGGR WQHKVWNWCD
     YGEFLYLKNI LGILSINWWL SFFGIRKVIY QKIQHARPWV DCPNRALVWG LPQFTRYMIT
     WLPIEMNARE LSRVNYQCAS RPGWNCLVDH TSTKLVASIG REGNDCHVEL AKEDLDVVLG
     LSTMQSVTSR LLQMGYKQPQ TLATVCQFYN SAAYDILSCS IVARPSQPPV HWPLASEIDQ
     PTTSFRNYSN NIVTCGNLCP QLKRWEVLSN SLEHRVTMVA NNKVPTPRIA RFAEEYVRLV
     VPEANVGVPY SLEDARKELD KPTQVNAVNQ IWETVDMEVR RLIEAFVKNE PTNKSGRIIS
     SFADSRFLLK FSTYTLAFRD EVLHAEHNRH WFCPGLTPNE IADKVCDYVR GVATPAEGDF
     SNFDGRVSAW CQENVMNAVY HRWFNRKFSK ELQKYTSMLV SCPARAKRFG FQYEPGVGVK
     SGSPTTCDLN SVLNNFTQYA AVRLTKPDLS PQEAFEQTGL SFGDDSLFDK QYQLRWNYVV
     EQLGMELKVE PFDPSNGVTF LARVFPDPYS TNTSFQDPLR TWRKLNMTSR TCVPVESAAL
     DRVSGYLVTD KYSPVTSEYC HMIERCYMNT AESVTRRRQR KDCDREKPYW LVSGGAWPQR
     EGDYELMMRV TAARTGFEES KLINLISQFQ SVHDPWDIKP LDYQEPSPYK DTLDIDGQPV
     DAVDERQYQN ERNTVNLRAG AAISQMPVPS VPGGEDCNRQ SADMPGPKSS EGSEQLQGLP
     EQDGSNRLQC HRQPTFKAKG GSNTKGRSRK SRNGGRSISS KTANPTTHEV GGGNGKTRVT
     IAKRSGPKRP HNVVSNAWET LNDNR