ID   RDS1_YEAST              Reviewed;         832 AA.
AC   P25611; D6VRA6;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Regulator of drug sensitivity 1;
GN   Name=RDS1; OrderedLocusNames=YCR106W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   PRESENCE OF A ZN(2)-CYS(6) FUNGAL-TYPE BINUCLEAR CLUSTER.
RX   PubMed=1641000; DOI=10.1038/358287a0;
RA   Bork P., Ouzounis C., Sander C., Scharf M., Schneider R., Sonnhammer E.;
RT   "What's in a genome?";
RL   Nature 358:287-287(1992).
RN   [4]
RP   FUNCTION.
RX   PubMed=11943786; DOI=10.1074/jbc.m202566200;
RA   Akache B., Turcotte B.;
RT   "New regulators of drug sensitivity in the family of yeast zinc cluster
RT   proteins.";
RL   J. Biol. Chem. 277:21254-21260(2002).
RN   [5]
RP   FUNCTION.
RX   PubMed=15343339; DOI=10.1038/nature02800;
RA   Harbison C.T., Gordon D.B., Lee T.I., Rinaldi N.J., Macisaac K.D.,
RA   Danford T.W., Hannett N.M., Tagne J.B., Reynolds D.B., Yoo J.,
RA   Jennings E.G., Zeitlinger J., Pokholok D.K., Kellis M., Rolfe P.A.,
RA   Takusagawa K.T., Lander E.S., Gifford D.K., Fraenkel E., Young R.A.;
RT   "Transcriptional regulatory code of a eukaryotic genome.";
RL   Nature 431:99-104(2004).
RN   [6]
RP   DNA-BINDING.
RX   PubMed=19158363; DOI=10.1101/gr.090233.108;
RA   Zhu C., Byers K.J., McCord R.P., Shi Z., Berger M.F., Newburger D.E.,
RA   Saulrieta K., Smith Z., Shah M.V., Radhakrishnan M., Philippakis A.A.,
RA   Hu Y., De Masi F., Pacek M., Rolfs A., Murthy T.V.S., Labaer J.,
RA   Bulyk M.L.;
RT   "High-resolution DNA-binding specificity analysis of yeast transcription
RT   factors.";
RL   Genome Res. 19:556-566(2009).
CC   -!- FUNCTION: Zinc cluster transcription factor involved in resistance to
CC       cycloheximide. {ECO:0000269|PubMed:11943786,
CC       ECO:0000269|PubMed:15343339}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; X59720; CAA42238.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07575.1; -; Genomic_DNA.
DR   PIR; S19418; S19418.
DR   RefSeq; NP_010031.1; NM_001178813.1.
DR   AlphaFoldDB; P25611; -.
DR   SMR; P25611; -.
DR   BioGRID; 31078; 43.
DR   DIP; DIP-2014N; -.
DR   IntAct; P25611; 24.
DR   MINT; P25611; -.
DR   STRING; 4932.YCR106W; -.
DR   MaxQB; P25611; -.
DR   PaxDb; P25611; -.
DR   PRIDE; P25611; -.
DR   EnsemblFungi; YCR106W_mRNA; YCR106W; YCR106W.
DR   GeneID; 850470; -.
DR   KEGG; sce:YCR106W; -.
DR   SGD; S000000703; RDS1.
DR   VEuPathDB; FungiDB:YCR106W; -.
DR   eggNOG; ENOG502RJ72; Eukaryota.
DR   GeneTree; ENSGT00940000176335; -.
DR   HOGENOM; CLU_015392_0_0_1; -.
DR   InParanoid; P25611; -.
DR   OMA; TIEDRMH; -.
DR   BioCyc; YEAST:G3O-29398-MON; -.
DR   PRO; PR:P25611; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P25611; protein.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IMP:SGD.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..832
FT                   /note="Regulator of drug sensitivity 1"
FT                   /id="PRO_0000114994"
FT   DNA_BIND        15..42
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   832 AA;  95690 MW;  7DF91D86AF08E4E3 CRC64;
     MDSITVKKPR LRLVCLQCKK IKRKCDKLRP ACSRCQQNSL QCEYEERTDL SANVAANDSD
     GFNSSHKLNF EQQPVLERTG LRYSLQVPEG VVNATLSIWN AEDMLVIVGL VTFLDYPFAA
     HSLAQHDQYI RALCASLYGM ALVDFSNYAN GIPCEDTSRS ILGPLSFIEK AIFRRIEHSK
     QFRVQSAALG LLYNAFSMEE ENFSTLLPSL IAEVEDVLMQ KKDCEILLRC FYQNIYPFYP
     FMDISLFESD LTSLLLQDDN NRWKISTEVK NVRKKIETLS LLTIVMAMAL MHSKLDANLL
     SMVKENASES ARKLSLLCHK LLCLLDVFRY PNENTFTCLL YFYVSEHLDP ESPDCVLSPT
     NLLTLHHLLN LSMTLGLQYE PSKYKRFKDP EVIRQRRILW LGVQSLLFQI SLAEGDAGKS
     NSEYMEAYLT DFEEYIEASS EYEKSSASES NVQMNDIVWN KYKFHVILSK LMSDCTSVIQ
     HPQLFHILGN IKRSEDFMAE NFPTSSIYQP LHEKEPNAIK VGKSTVLDVM DIQKTEIFLT
     NIVGSMCFLN IFDVLSLHFE KKCVMHWEEY EKNYHFLTLK SFNAYLKLAG LISDYLENKF
     QGNILESRGY IIDKQICFML VRIWMFQCRI LLRFSYKQES QKKLASSSIS TNDNEKEDEM
     IVILERLIKH IRNQMAHLVD LAKGKLQDSY FGAYQTVPMF RYVVYLIDVG GLVSVTNGFW
     DKISSDGEIP PKVQQAVRLK WGLDCNNSRR IKQKLISSQS LQSFNQVLLC QMEDAVLSSS
     FAIKANTAMS QNTAEEFFNI SEEEALNQLL ENNNFDAFWD LLGENLSDMP SL