ID   RDXA_HELAH              Reviewed;         210 AA.
AC   Q17X32;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Oxygen-insensitive NADPH nitroreductase;
DE            EC=1.-.-.-;
GN   Name=rdxA; OrderedLocusNames=Hac_1030;
OS   Helicobacter acinonychis (strain Sheeba).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=382638;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheeba;
RX   PubMed=16789826; DOI=10.1371/journal.pgen.0020120;
RA   Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G.,
RA   Gressmann H., Achtman M., Schuster S.C.;
RT   "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a
RT   host jump from early humans to large felines.";
RL   PLoS Genet. 2:1097-1110(2006).
CC   -!- FUNCTION: Reduction of a variety of nitroaromatic compounds using NADPH
CC       as source of reducing equivalents; two electrons are transferred.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; AM260522; CAJ99794.1; -; Genomic_DNA.
DR   RefSeq; WP_011577904.1; NC_008229.1.
DR   AlphaFoldDB; Q17X32; -.
DR   SMR; Q17X32; -.
DR   STRING; 382638.Hac_1030; -.
DR   EnsemblBacteria; CAJ99794; CAJ99794; Hac_1030.
DR   KEGG; hac:Hac_1030; -.
DR   eggNOG; COG0778; Bacteria.
DR   HOGENOM; CLU_070764_10_0_7; -.
DR   OMA; EQCYIAV; -.
DR   OrthoDB; 1847197at2; -.
DR   BioCyc; HACI382638:HAC_RS04415-MON; -.
DR   Proteomes; UP000000775; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02149; NfsB-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR033878; NfsB-like.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase.
FT   CHAIN           1..210
FT                   /note="Oxygen-insensitive NADPH nitroreductase"
FT                   /id="PRO_0000321865"
FT   BINDING         150..155
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  24090 MW;  04DE9B98DFE4C9FA CRC64;
     MKFLNQEKRK QLLNERHSCK MFDKHYTFSS EELEEIAEIA RLSPSSYNTQ PWHFVMVTNK
     DLKNQIAAHS YFNKDMIESA SALVVVCSLK PVELLPNGHY MQNLYDEPYR SRTLLSFAQM
     LDLRFNHSMQ KLESYILEQC YIAVGQICLG VSLMGLDSCI IGGFDALKVG EVLSQRINDP
     KIACLIALGK RVKEASQKSR KPKNHAITWL