ID   RDXA_HELPH              Reviewed;         210 AA.
AC   Q1CSR7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Oxygen-insensitive NADPH nitroreductase;
DE            EC=1.-.-.-;
GN   Name=rdxA; OrderedLocusNames=HPAG1_0938;
OS   Helicobacter pylori (strain HPAG1).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=357544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HPAG1;
RX   PubMed=16788065; DOI=10.1073/pnas.0603784103;
RA   Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A.,
RA   Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G.,
RA   Gordon J.I.;
RT   "The complete genome sequence of a chronic atrophic gastritis Helicobacter
RT   pylori strain: evolution during disease progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006).
CC   -!- FUNCTION: Reduction of a variety of nitroaromatic compounds using NADPH
CC       as source of reducing equivalents; two electrons are transferred.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nitroreductase family. {ECO:0000305}.
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DR   EMBL; CP000241; ABF85005.1; -; Genomic_DNA.
DR   RefSeq; WP_000670132.1; NC_008086.1.
DR   AlphaFoldDB; Q1CSR7; -.
DR   SMR; Q1CSR7; -.
DR   EnsemblBacteria; ABF85005; ABF85005; HPAG1_0938.
DR   KEGG; hpa:HPAG1_0938; -.
DR   HOGENOM; CLU_070764_10_0_7; -.
DR   OMA; EQCYIAV; -.
DR   OrthoDB; 1847197at2; -.
DR   Proteomes; UP000008835; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02149; NfsB-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR033878; NfsB-like.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase.
FT   CHAIN           1..210
FT                   /note="Oxygen-insensitive NADPH nitroreductase"
FT                   /id="PRO_0000321866"
FT   BINDING         150..155
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  24095 MW;  70EFBD7B2179A34F CRC64;
     MKFLDQEKRR RLLNERHSCK MFDSHYEFSS TELEEIAEIA RLSPSSYNTQ PWHFVMVTNK
     DLKKQIAAHS YFNEEMIKSA SALMVVCSLR PSELLPHGHY MQNLYPESYK VRVIPSFAQM
     LGVRFNHSMQ RLESYILEQC YIAVGQICMG VSLMGLDSCI IGGFDPLKVG EVLEERINKP
     KIACLIALGK RVAEASQKSR KSKVDAITWL