RE104_YEAST
ID RE104_YEAST Reviewed; 182 AA.
AC P33323; D3DLA6;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Meiotic recombination protein REC104;
GN Name=REC104; OrderedLocusNames=YHR157W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8462842; DOI=10.1093/genetics/133.4.785;
RA Hollingsworth N.M., Johnson A.D.;
RT "A conditional allele of the Saccharomyces cerevisiae HOP1 gene is
RT suppressed by overexpression of two other meiosis-specific genes: RED1 and
RT REC104.";
RL Genetics 133:785-797(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1304422; DOI=10.1002/dvg.1020130603;
RA Galbraith A.M., Malone R.E.;
RT "Characterization of REC104, a gene required for early meiotic
RT recombination in the yeast Saccharomyces cerevisiae.";
RL Dev. Genet. 13:392-402(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP INTERACTION WITH REC114 AND SPO11.
RX PubMed=14992724; DOI=10.1016/s1097-2765(04)00063-2;
RA Arora C., Kee K., Maleki S., Keeney S.;
RT "Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break
RT formation, independent of its cytoplasmic role in RNA metabolism.";
RL Mol. Cell 13:549-559(2004).
CC -!- FUNCTION: Potential transcriptional regulator that is required to
CC activate expression of a number of early meiotic genes including HOP1.
CC -!- SUBUNIT: Interacts with REC114 and SPO11.
CC {ECO:0000269|PubMed:14992724}.
CC -!- INTERACTION:
CC P33323; P29467: MEI4; NbExp=5; IntAct=EBI-16412992, EBI-2566907;
CC P33323; Q02721: REC102; NbExp=6; IntAct=EBI-16412992, EBI-14432;
CC P33323; P23179: SPO11; NbExp=7; IntAct=EBI-16412992, EBI-17705;
CC -!- DEVELOPMENTAL STAGE: Meiosis-specific.
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DR EMBL; S58278; AAB26085.1; -; Genomic_DNA.
DR EMBL; U10397; AAB68976.1; -; Genomic_DNA.
DR EMBL; AY558285; AAS56611.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06850.1; -; Genomic_DNA.
DR PIR; S46667; S46667.
DR RefSeq; NP_012027.1; NM_001179288.1.
DR AlphaFoldDB; P33323; -.
DR BioGRID; 36591; 92.
DR ComplexPortal; CPX-1292; REC102-REC104 meiotic recombination initiation complex.
DR DIP; DIP-7960N; -.
DR IntAct; P33323; 8.
DR STRING; 4932.YHR157W; -.
DR PaxDb; P33323; -.
DR EnsemblFungi; YHR157W_mRNA; YHR157W; YHR157W.
DR GeneID; 856562; -.
DR KEGG; sce:YHR157W; -.
DR SGD; S000001200; REC104.
DR VEuPathDB; FungiDB:YHR157W; -.
DR HOGENOM; CLU_127241_0_0_1; -.
DR OMA; ILGDPVC; -.
DR BioCyc; YEAST:G3O-31192-MON; -.
DR PRO; PR:P33323; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P33323; protein.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:SGD.
DR GO; GO:0042138; P:meiotic DNA double-strand break formation; IDA:ComplexPortal.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
DR InterPro; IPR035349; Rec104.
DR Pfam; PF17378; REC104; 1.
PE 1: Evidence at protein level;
KW Activator; Meiosis; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..182
FT /note="Meiotic recombination protein REC104"
FT /id="PRO_0000097216"
SQ SEQUENCE 182 AA; 20744 MW; 65667529FA02B1D8 CRC64;
MSIEEEDTNK ITCTQDFLHQ YFVTERVSIQ FGLNNKTVKR INKDEFDKAV NCIMSWTNYP
KPGLKRTAST YLLSNSFKKS ATVSLPFILG DPVCMPKRVE SNNNDTCLLY SDTLYDDPLI
QRNDQAGDEI EDEFSFTLLR SEVNEIRPIS SSSTAQILQS DYSALMYERQ ASNGSIFQFS
SP
