ID   REC04_HUMAN             Reviewed;         105 AA.
AC   P61576;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Endogenous retrovirus group K member 104 Rec protein;
DE   AltName: Full=HERV-K104 Rec protein;
DE   AltName: Full=HERV-K_5q13.3 provirus Rec protein;
GN   Name=HERV-K104;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10469592; DOI=10.1016/s0960-9822(99)80390-x;
RA   Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J.;
RT   "Many human endogenous retrovirus K (HERV-K) proviruses are unique to
RT   humans.";
RL   Curr. Biol. 9:861-868(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=15063128; DOI=10.1016/j.virol.2004.01.023;
RA   Mayer J., Ehlhardt S., Seifert M., Sauter M., Mueller-Lantzsch N.,
RA   Mehraein Y., Zang K.-D., Meese E.U.;
RT   "Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein
RT   coding capacity and transcriptional activity.";
RL   Virology 322:190-198(2004).
CC   -!- FUNCTION: Retroviral replication requires the nuclear export and
CC       translation of unspliced, singly-spliced and multiply-spliced
CC       derivatives of the initial genomic transcript. Rec interacts with a
CC       highly structured RNA element (RcRE) present in the viral 3'LTR and
CC       recruits the cellular nuclear export machinery. This permits export to
CC       the cytoplasm of unspliced genomic or incompletely spliced subgenomic
CC       viral transcripts (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms homodimers, homotrimers, and homotetramers via a C-
CC       terminal domain. Associates with XPO1 and with ZNF145 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm.
CC       When in the nucleus, resides in the nucleolus (By similarity).
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Despite functional similarity, Rec shares almost no
CC       sequence homology with HIV-1 Rev and HTLV-1 Rex.
CC   -!- MISCELLANEOUS: This Rec protein is encoded by a human specific
CC       provirus.
CC   -!- MISCELLANEOUS: HERV-K104 has a type 2 genome. The HERV-K(HML-2) family
CC       contains type 1 and type 2 genomes depending on the absence or presence
CC       of 292 nucleotides at the 5'-end of the env gene. Rec proteins are
CC       translated from a doubly spliced transcript expressed exclusively by
CC       HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87
CC       N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein.
CC       The second exon (18 amino acids) is positioned in the 3' part of the
CC       proviral genome.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF164612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC025757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P61576; -.
DR   SMR; P61576; -.
DR   BioMuta; HERV-K104; -.
DR   MassIVE; P61576; -.
DR   PRIDE; P61576; -.
DR   neXtProt; NX_P61576; -.
DR   PhylomeDB; P61576; -.
DR   Pharos; P61576; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P61576; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; ERV; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW   Transport; Transposable element.
FT   CHAIN           1..105
FT                   /note="Endogenous retrovirus group K member 104 Rec
FT                   protein"
FT                   /id="PRO_0000186780"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           13..20
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           50..59
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        63
FT                   /note="C -> Y (in Ref. 1; AF164612)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   105 AA;  11735 MW;  C9614D0AB887D9F3 CRC64;
     MNPSEMQRKA PPRRRRHCNR APLTHKMNKM VTSEEEMKLP STKKAEPLTW AQLKKLTQLA
     TKCLENTKVT QTPESMLLAA LMIVSMVSAG VTNSSKETAT IENGP