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REC14_SCHPO
ID   REC14_SCHPO             Reviewed;         302 AA.
AC   Q09150;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 135.
DE   RecName: Full=Meiotic recombination protein rec14;
GN   Name=rec14 {ECO:0000303|PubMed:9258671};
GN   ORFNames=SPBC32F12.02 {ECO:0000312|PomBase:SPBC32F12.02};
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9258671; DOI=10.1093/genetics/146.4.1253;
RA   Evans D.H., Li Y.F., Fox M.E., Smith G.R.;
RT   "A WD repeat protein, Rec14, essential for meiotic recombination in
RT   Schizosaccharomyces pombe.";
RL   Genetics 146:1253-1264(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   FUNCTION.
RX   PubMed=10882124; DOI=10.1016/s1097-2765(00)80328-7;
RA   Cervantes M.D., Farah J.A., Smith G.R.;
RT   "Meiotic DNA breaks associated with recombination in S. pombe.";
RL   Mol. Cell 5:883-888(2000).
RN   [4]
RP   IDENTIFICATION IN DSBC COMPLEX, AND INTERACTION WITH MDE2.
RX   PubMed=22841486; DOI=10.1016/j.molcel.2012.06.023;
RA   Miyoshi T., Ito M., Kugou K., Yamada S., Furuichi M., Oda A., Yamada T.,
RA   Hirota K., Masai H., Ohta K.;
RT   "A central coupler for recombination initiation linking chromosome
RT   architecture to S phase checkpoint.";
RL   Mol. Cell 47:722-733(2012).
CC   -!- FUNCTION: Required for formation of the rec12-mediated double-strand
CC       breaks (DSBs) that initiate meiotic recombination.
CC       {ECO:0000269|PubMed:10882124}.
CC   -!- SUBUNIT: Component of the DSB catalytic core (DSBC) complex, composed
CC       of at least rec12, rec6 and rec14. The complex interacts with mde2.
CC       {ECO:0000269|PubMed:22841486}.
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DR   EMBL; U39144; AAB71433.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAA19363.1; -; Genomic_DNA.
DR   PIR; T40226; T40226.
DR   RefSeq; NP_596145.1; NM_001022064.2.
DR   AlphaFoldDB; Q09150; -.
DR   SMR; Q09150; -.
DR   BioGRID; 276754; 80.
DR   STRING; 4896.SPBC32F12.02.1; -.
DR   MaxQB; Q09150; -.
DR   PaxDb; Q09150; -.
DR   EnsemblFungi; SPBC32F12.02.1; SPBC32F12.02.1:pep; SPBC32F12.02.
DR   GeneID; 2540221; -.
DR   KEGG; spo:SPBC32F12.02; -.
DR   PomBase; SPBC32F12.02; rec14.
DR   VEuPathDB; FungiDB:SPBC32F12.02; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   HOGENOM; CLU_000288_57_11_1; -.
DR   InParanoid; Q09150; -.
DR   OMA; VGFSPCN; -.
DR   PhylomeDB; Q09150; -.
DR   Reactome; R-SPO-429958; mRNA decay by 3' to 5' exoribonuclease.
DR   Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-SPO-75955; RNA Polymerase II Transcription Elongation.
DR   PRO; PR:Q09150; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0016593; C:Cdc73/Paf1 complex; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0055087; C:Ski complex; ISO:PomBase.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; ISO:PomBase.
DR   GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISO:PomBase.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Meiosis; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..302
FT                   /note="Meiotic recombination protein rec14"
FT                   /id="PRO_0000051198"
FT   REPEAT          14..51
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          57..96
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          101..140
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          142..184
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          185..226
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          227..266
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          269..302
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  32936 MW;  7F650E98A7E1EEB7 CRC64;
     MRKEYLVSHI EENAHQADIY SLNVVAGNLW SASGDSKIKK WSIGDAEHSL VEEIDTPHKL
     GVHHLATSLD ENVVVSCGFG QDVYVWNPET NEFRDLGNNA QHPSECWSSC ISPDGQTIAF
     TSVDGRIAVW DNPSDCKISE LDTKGKFGLC IDYSPNGRFI VSGHQTGQLF LISTETGRLF
     HVLSGHTSPV RSVAFSPGST LLAAAGDSKM ITIYDVLSGD QVGQLRGHAA WIFAVAFNPV
     GDLLLSADVE GKIKIWDIDT MECISTQSET DGAIWAVAWY KNGFIVAGAD KSIRWYRAAA
     TE
 
 
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