REC15_SCHPO
ID REC15_SCHPO Reviewed; 180 AA.
AC Q09094;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Meiotic recombination protein rec15 {ECO:0000312|PomBase:SPBC1711.14};
GN Name=rec15 {ECO:0000303|PubMed:8559063};
GN ORFNames=SPBC1711.14 {ECO:0000312|PomBase:SPBC1711.14};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8559063; DOI=10.1111/j.1365-2958.1995.mmi_17030439.x;
RA Lin Y., Smith G.R.;
RT "An intron-containing meiosis-induced recombination gene, rec15, of
RT Schizosaccharomyces pombe.";
RL Mol. Microbiol. 17:439-448(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16252089; DOI=10.1007/s00294-005-0024-3;
RA Doll E., Molnar M., Hiraoka Y., Kohli J.;
RT "Characterization of rec15, an early meiotic recombination gene in
RT Schizosaccharomyces pombe.";
RL Curr. Genet. 48:323-333(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [5]
RP SUBUNIT, INTERACTION WITH HOP1; REC10 AND MDE2, SUBCELLULAR LOCATION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=31665745; DOI=10.1093/nar/gkz754;
RA Kariyazono R., Oda A., Yamada T., Ohta K.;
RT "Conserved HORMA domain-containing protein Hop1 stabilizes interaction
RT between proteins of meiotic DNA break hotspots and chromosome axis.";
RL Nucleic Acids Res. 47:10166-10180(2019).
CC -!- FUNCTION: Required during the early stages of meiosis for meiotic
CC recombination. {ECO:0000269|PubMed:16252089}.
CC -!- SUBUNIT: Homomer (PubMed:31665745). Interacts (via C-terminus) with
CC hop1 (via C-terminus); the interaction is direct (PubMed:31665745).
CC Interacts (via C-terminus) with rec10; the interaction is direct
CC (PubMed:31665745). Interacts with mde2; the interaction is direct
CC (PubMed:31665745). {ECO:0000269|PubMed:31665745}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16252089,
CC ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:31665745}. Chromosome
CC {ECO:0000269|PubMed:31665745}. Note=Localizes to meiotic chromosomal
CC axis sites and DNA double-strand break (DSB) hotspots.
CC {ECO:0000269|PubMed:31665745}.
CC -!- DISRUPTION PHENOTYPE: Abolishes localization of hop1 to DNA double-
CC strand break (DSB) hotspots. {ECO:0000269|PubMed:31665745}.
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DR EMBL; U09872; AAA98494.1; -; Unassigned_DNA.
DR EMBL; CU329671; CAB88244.1; -; Genomic_DNA.
DR PIR; S70725; S70725.
DR RefSeq; NP_595887.1; NM_001021793.2.
DR AlphaFoldDB; Q09094; -.
DR SMR; Q09094; -.
DR BioGRID; 276273; 8.
DR STRING; 4896.SPBC1711.14.1; -.
DR PaxDb; Q09094; -.
DR EnsemblFungi; SPBC1711.14.1; SPBC1711.14.1:pep; SPBC1711.14.
DR GeneID; 2539720; -.
DR KEGG; spo:SPBC1711.14; -.
DR PomBase; SPBC1711.14; rec15.
DR VEuPathDB; FungiDB:SPBC1711.14; -.
DR HOGENOM; CLU_1497079_0_0_1; -.
DR OMA; MQAEDMQ; -.
DR PRO; PR:Q09094; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.
PE 1: Evidence at protein level;
KW Chromosome; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..180
FT /note="Meiotic recombination protein rec15"
FT /id="PRO_0000097222"
SQ SEQUENCE 180 AA; 20507 MW; E9FCC80EA3E0B343 CRC64;
MSYSVSAAQL WSRKLAMQAE DMQQHQKSQS NQIASCLAEM NTKQEVVNQT IGQLGRSISE
VQQQNSQLVL QSLNQINMSM QQVALGIQDY ASRINKLEQT MSDMNLKFEA LQKEQNSNTK
TLADCTSQMT IITKKLDAEL KKRYMTTKQT RTVQNQTMPR SNTTTKKRVL AIDFLADDDY
