REC2_HAEIN
ID REC2_HAEIN Reviewed; 788 AA.
AC P44408;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Recombination protein 2;
GN Name=rec2; Synonyms=rec-2; OrderedLocusNames=HI_0061;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BC200;
RX PubMed=8063112; DOI=10.1016/0378-1119(94)90840-0;
RA Clifton S.W., McCarthy D., Roe B.A.;
RT "Sequence of the rec-2 locus of Haemophilus influenzae: homologies to comE-
RT ORF3 of Bacillus subtilis and msbA of Escherichia coli.";
RL Gene 146:95-100(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Might contribute to transformation as a member of a membrane-
CC bound pore complex at the base of the transformasome. It could directly
CC interact with transforming DNA during translocation indirectly by
CC participating in the assembly of the pore.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
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DR EMBL; L20805; AAC13733.1; -; Genomic_DNA.
DR EMBL; L42023; AAC21739.1; -; Genomic_DNA.
DR PIR; I64045; I64045.
DR RefSeq; NP_438234.1; NC_000907.1.
DR RefSeq; WP_005693861.1; NC_000907.1.
DR AlphaFoldDB; P44408; -.
DR SMR; P44408; -.
DR STRING; 71421.HI_0061; -.
DR TCDB; 3.A.11.2.2; the bacterial competence-related dna transformation transporter (dna-t) family.
DR EnsemblBacteria; AAC21739; AAC21739; HI_0061.
DR KEGG; hin:HI_0061; -.
DR PATRIC; fig|71421.8.peg.61; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_3_0_6; -.
DR OMA; RTDKQGA; -.
DR PhylomeDB; P44408; -.
DR BioCyc; HINF71421:G1GJ1-62-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; -; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; SSF56281; 1.
DR TIGRFAMs; TIGR00360; ComEC_N-term; 1.
DR TIGRFAMs; TIGR00361; ComEC_Rec2; 1.
PE 4: Predicted;
KW Cell inner membrane; Cell membrane; Competence; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..788
FT /note="Recombination protein 2"
FT /id="PRO_0000097224"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 748..788
FT /note="VENTAVSGQVRVNFFQDRLEIQQARTKFSPWYARVIGLSKE -> GRKYRCF
FT GASAGKFFSRPIRNPASSHKIFPLVCACNWIIKGIKGTMRAIFTIR (in Ref. 1;
FT AAC13733)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 788 AA; 89356 MW; F31104595CB4E47A CRC64;
MKLNLITLVV LLIVADLTLL FLPQPLLLPW QVALVIALVL IFLFIFLRRN FLVSLAFFVA
SLGYFHYSAL SLSQQAQNIT AQKQVVTFKI QEILHQQDYQ TLIATATLEN NLQEQRIFLN
WKAKEVPQLS EIWQAEISLR SLSARLNFGG FDRQQWYFSK GITAVGTVKS AVKIADVSSL
RAEKLQQVKK QTEGLSLQGL LIALAFGERA WLDKTTWSIY QQTNTAHLIA ISGLHIGLAM
GIGFCLARVV QVFFPTRFIH PYFPLVFGVL FALIYAYLAG FSVPTFRAIS ALVFVLFIQI
MRRHYSPIQF FTLVVGFLLF CDPLMPLSVS FWLSCGAVGC LLLWYRYVPF SLFQWKNRPF
SPKVRWIFSL FHLQFGLLLF FTPLQLFLFN GLSLSGFLAN FMAVPIYSFL LVPLILFAVF
TNGTMFSWQL ANKLAEGITG LISVFQGNWL TVSFNLALGL TALCAGIFML IIWNIYREPE
ISSSNWQIKR AKFFTLNLSK PLLKNERINV LRCSFGIILL CFTILLFKQL SKPTWQVDTL
DVGQGLATLI VKNGKGILYD TGSSWRGGSM AELEILPYLQ REGIVLEKLI LSHDDNDHAG
GASTILKAYP NVELITPSRK NYGENYRTFC TAGRDWHWQG LHFQILSPHN VVTRADNSHS
CVILVDDGKN SVLLTGDAEA KNEQIFARTL GKIDVLQVGH HGSKTSTSEY LLSQVRPDVA
IISSGRWNPW KFPHYSVMER LHRYKSAVEN TAVSGQVRVN FFQDRLEIQQ ARTKFSPWYA
RVIGLSKE
