REC9_HUMAN
ID REC9_HUMAN Reviewed; 105 AA.
AC P61573;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Endogenous retrovirus group K member 9 Rec protein;
DE AltName: Full=HERV-K(C6) Rec protein;
DE AltName: Full=HERV-K109 Rec protein;
DE AltName: Full=HERV-K_6q14.1 provirus Rec protein;
GN Name=ERVK-9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10469592; DOI=10.1016/s0960-9822(99)80390-x;
RA Barbulescu M., Turner G., Seaman M.I., Deinard A.S., Kidd K.K., Lenz J.;
RT "Many human endogenous retrovirus K (HERV-K) proviruses are unique to
RT humans.";
RL Curr. Biol. 9:861-868(1999).
RN [3]
RP CHARACTERIZATION.
RX PubMed=15063128; DOI=10.1016/j.virol.2004.01.023;
RA Mayer J., Ehlhardt S., Seifert M., Sauter M., Mueller-Lantzsch N.,
RA Mehraein Y., Zang K.-D., Meese E.U.;
RT "Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein
RT coding capacity and transcriptional activity.";
RL Virology 322:190-198(2004).
CC -!- FUNCTION: Retroviral replication requires the nuclear export and
CC translation of unspliced, singly-spliced and multiply-spliced
CC derivatives of the initial genomic transcript. Rec interacts with a
CC highly structured RNA element (RcRE) present in the viral 3'LTR and
CC recruits the cellular nuclear export machinery. This permits export to
CC the cytoplasm of unspliced genomic or incompletely spliced subgenomic
CC viral transcripts (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms homodimers, homotrimers, and homotetramers via a C-
CC terminal domain. Associates with XPO1 and with ZNF145 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm.
CC When in the nucleus, resides in the nucleolus (By similarity).
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Despite functional similarity, Rec shares almost no
CC sequence homology with HIV-1 Rev and HTLV-1 Rex.
CC -!- MISCELLANEOUS: This Rec protein is encoded by a human specific
CC provirus.
CC -!- MISCELLANEOUS: ERVK-9 has a type 2 genome. The HERV-K(HML-2) family
CC contains type 1 and type 2 genomes depending on the absence or presence
CC of 292 nucleotides at the 5'-end of the env gene. Rec proteins are
CC translated from a doubly spliced transcript expressed exclusively by
CC HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87
CC N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein.
CC The second exon (18 amino acids) is positioned in the 3' part of the
CC proviral genome.
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DR EMBL; AL590785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF164615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P61573; -.
DR SMR; P61573; -.
DR BioMuta; HGNC:39005; -.
DR MassIVE; P61573; -.
DR PRIDE; P61573; -.
DR GeneCards; ERVK-9; -.
DR HGNC; HGNC:39005; ERVK-9.
DR neXtProt; NX_P61573; -.
DR PhylomeDB; P61573; -.
DR Pharos; P61573; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cytoplasm; ERV; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW Transport; Transposable element.
FT CHAIN 1..105
FT /note="Endogenous retrovirus group K member 9 Rec protein"
FT /id="PRO_0000186777"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 13..20
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 50..59
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 10..24
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 105 AA; 11828 MW; 9935AF374750102F CRC64;
MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA
TKYLENTKVT QTPESMLLAA LMIVSMVSAG VPNSSEETAT IENGP
