RECAM_DICDI
ID RECAM_DICDI Reviewed; 452 AA.
AC Q75JL2; Q552B2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Mitochondrial DNA repair protein recA homolog;
DE AltName: Full=Recombinase A homolog;
GN Name=recA; ORFNames=DDB_G0276073;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION, FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15084313; DOI=10.1016/j.dnarep.2004.01.014;
RA Hasegawa Y., Wakabayashi M., Nakamura S., Kodaira K., Shinohara H.,
RA Yasukawa H.;
RT "A homolog of Escherichia coli RecA in mitochondria of the cellular slime
RT mold Dictyostelium discoideum.";
RL DNA Repair 3:515-525(2004).
CC -!- FUNCTION: Involved in DNA recombination ability. Important for survival
CC following exposure to DNA damaging agents.
CC {ECO:0000269|PubMed:15084313}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:15084313}.
CC -!- SIMILARITY: Belongs to the RecA family. {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69336.1; -; Genomic_DNA.
DR EMBL; BR000215; FAA00018.1; -; Genomic_DNA.
DR RefSeq; XP_643316.1; XM_638224.1.
DR AlphaFoldDB; Q75JL2; -.
DR SMR; Q75JL2; -.
DR STRING; 44689.DDB0231571; -.
DR PaxDb; Q75JL2; -.
DR PRIDE; Q75JL2; -.
DR EnsemblProtists; EAL69336; EAL69336; DDB_G0276073.
DR GeneID; 8620362; -.
DR KEGG; ddi:DDB_G0276073; -.
DR dictyBase; DDB_G0276073; recA.
DR eggNOG; KOG1433; Eukaryota.
DR HOGENOM; CLU_040469_0_2_1; -.
DR InParanoid; Q75JL2; -.
DR OMA; DYGEQAL; -.
DR PhylomeDB; Q75JL2; -.
DR PRO; PR:Q75JL2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005739; C:mitochondrion; IDA:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IGI:dictyBase.
DR CDD; cd00983; recA; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00268; RecA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013765; DNA_recomb/repair_RecA.
DR InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR023400; RecA_C.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45900; PTHR45900; 1.
DR Pfam; PF00154; RecA; 1.
DR PRINTS; PR00142; RECA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54752; SSF54752; 1.
DR TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR PROSITE; PS00321; RECA_1; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA recombination; DNA-binding; Mitochondrion;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..452
FT /note="Mitochondrial DNA repair protein recA homolog"
FT /id="PRO_0000312854"
FT REGION 53..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..445
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 147..154
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 452 AA; 49782 MW; C7219B971957A3BE CRC64;
MSINKILSST YKITQRSNNN NILFNGLKIN SFSLCNTKTN LFTNKTNINL YNNYSKSSKS
GKKSKKDEDD EDGEIETSKT SKKSASSSSM ENVLKELEKS FGKGTLMKLG SQFSTQKVEV
IPSGSMGLDI ALGVGGLPKG RVTEIFGPES SGKTTLALHV IAQAQKAGGN CTFIDAEHAL
NPQWAARLGV NLDELFVSQP DNGEQALEIV DSLLRSKTMS VIVVDSVAAL VPRVEIEGEM
GDSHLGVQAR LMSQALRKLS PTLKDSNCVL IFINQIRMKI GVMFGNPEVT SGGNALKFFS
SIRIDIRKVG TVKKGDDIIA SQVKAKVVKN KLAPPFKEAI FDIDFQSGIN KTGEIIDLAV
AEGIIDKMGS WYSYNDIKLD QGREKTKYLL EKTQPNLLVE IENKLRDKLI KSKPLINQQQ
EEEGNDQTSD EFDIENDDEI IEEDIDDETI KK
