ID   RECA_BACTN              Reviewed;         330 AA.
AC   Q45791;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 3.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE   AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN   Name=recA {ECO:0000255|HAMAP-Rule:MF_00268}; OrderedLocusNames=BT_4610;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-199.
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=9335266; DOI=10.1128/jb.179.20.6221-6227.1997;
RA   Cooper A.J., Kalinowski A.P., Shoemaker N.B., Salyers A.A.;
RT   "Construction and characterization of a Bacteroides thetaiotaomicron recA
RT   mutant: transfer of Bacteroides integrated conjugative elements is RecA
RT   independent.";
RL   J. Bacteriol. 179:6221-6227(1997).
CC   -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC       stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC       DNA, and the ATP-dependent hybridization of homologous single-stranded
CC       DNAs. It interacts with LexA causing its activation and leading to its
CC       autocatalytic cleavage. {ECO:0000255|HAMAP-Rule:MF_00268}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC   -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00268}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO79715.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015928; AAO79715.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U63514; AAB81399.1; -; Genomic_DNA.
DR   RefSeq; NP_813521.1; NC_004663.1.
DR   AlphaFoldDB; Q45791; -.
DR   SMR; Q45791; -.
DR   STRING; 226186.BT_4610; -.
DR   PaxDb; Q45791; -.
DR   PRIDE; Q45791; -.
DR   EnsemblBacteria; AAO79715; AAO79715; BT_4610.
DR   KEGG; bth:BT_4610; -.
DR   PATRIC; fig|226186.12.peg.4689; -.
DR   eggNOG; COG0468; Bacteria.
DR   HOGENOM; CLU_040469_3_2_10; -.
DR   InParanoid; Q45791; -.
DR   OMA; DYGEQAL; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd00983; recA; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00268; RecA; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013765; DNA_recomb/repair_RecA.
DR   InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR023400; RecA_C.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   PANTHER; PTHR45900; PTHR45900; 1.
DR   Pfam; PF00154; RecA; 1.
DR   PRINTS; PR00142; RECA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54752; SSF54752; 1.
DR   TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR   PROSITE; PS00321; RECA_1; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW   DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT   CHAIN           1..330
FT                   /note="Protein RecA"
FT                   /id="PRO_0000122657"
FT   BINDING         66..73
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
SQ   SEQUENCE   330 AA;  35545 MW;  5D0E595592AF37E6 CRC64;
     MASSEKLKAL QATMEKIEKN FGKGSIMKMG DDSVEQVEVI PTGSIALNVA LGVGGYPRGR
     IIEIYGPESS GKTTLAIHAI AEAQKAGGIA AFIDAEHAFD RFYAAKLGVD VDNLWISQPD
     NGEQALEIAE QLIRSSAIDI IVIDSVAALT PKAEIEGDMG DNKVGLQARL MSQALRKLTG
     TVSKTRTTCI FINQLREKIG VMFGNPETTT GGNALKFYAS VRIDIRGSQP IKDGEEVLGK
     LTKVKVVKNK VAPPFRKAEF DIMFGEGISH SGEIIDLGAE LGIIKKSGSW YSYNDTKLGQ
     GRDAAKVCIK DNPELAEELE GLIFEALNKK