RECA_HAEIN
ID RECA_HAEIN Reviewed; 354 AA.
AC P43705;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE AltName: Full=Recombinase 1;
DE AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN Name=recA {ECO:0000255|HAMAP-Rule:MF_00268}; Synonyms=rec-1, rec1;
GN OrderedLocusNames=HI_0600;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=8226674; DOI=10.1128/jb.175.22.7269-7281.1993;
RA Zulty J.J., Barcak G.J.;
RT "Structural organization, nucleotide sequence, and regulation of the
RT Haemophilus influenzae rec-1+ gene.";
RL J. Bacteriol. 175:7269-7281(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC DNA, and the ATP-dependent hybridization of homologous single-stranded
CC DNAs. It interacts with LexA causing its activation and leading to its
CC autocatalytic cleavage. Plays a central role in DNA metabolism,
CC participating in general homologous recombination, recombinational
CC (postreplication) DNA repair, and prophage induction.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC Rule:MF_00268}.
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DR EMBL; L07529; AAC36817.1; -; Unassigned_DNA.
DR EMBL; L42023; AAC22257.1; -; Genomic_DNA.
DR PIR; A49929; A49929.
DR RefSeq; NP_438757.1; NC_000907.1.
DR RefSeq; WP_005654959.1; NC_000907.1.
DR AlphaFoldDB; P43705; -.
DR SMR; P43705; -.
DR STRING; 71421.HI_0600; -.
DR EnsemblBacteria; AAC22257; AAC22257; HI_0600.
DR KEGG; hin:HI_0600; -.
DR PATRIC; fig|71421.8.peg.621; -.
DR eggNOG; COG0468; Bacteria.
DR HOGENOM; CLU_040469_3_2_6; -.
DR OMA; EGARHMS; -.
DR PhylomeDB; P43705; -.
DR BioCyc; HINF71421:G1GJ1-610-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEP:CollecTF.
DR CDD; cd00983; recA; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00268; RecA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013765; DNA_recomb/repair_RecA.
DR InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR023400; RecA_C.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45900; PTHR45900; 1.
DR Pfam; PF00154; RecA; 1.
DR PRINTS; PR00142; RECA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54752; SSF54752; 1.
DR TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR PROSITE; PS00321; RECA_1; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT CHAIN 1..354
FT /note="Protein RecA"
FT /id="PRO_0000122722"
FT BINDING 67..74
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
SQ SEQUENCE 354 AA; 38133 MW; C25C01D2FD4AF7C5 CRC64;
MATQEEKQKA LAAALGQIEK QFGKGSIMKL GDTKTLDVES ISTGSLGLDV ALGIGGLPMG
RIVEIFGPES SGKTTLTLSV IAQAQKAGKT CAFIDAEHAL DPIYAAKLGV DVKELFVSQP
DNGEQALEIC DALVRSGAID VIIVDSVAAL TPKAEIEGDM GDSHMGLQAR LMSQALRKLT
GQIKNANCLV VFINQIRMKI GVMFGNPETT TGGNALKFYS SVRLDIRRTG SVKDGENIIG
NETRVKVVKN KLAAPFRQVD FQILYGEGIS KAGELLELGV KHKLVEKSGA WYSYNGEKIG
QGKANSMKWL NENIEKSDEL EARLRAELVA NPEQALMADI EQSENNTESE SDFE
