ID   RECA_LEGPN              Reviewed;         348 AA.
AC   Q05358; Q9AKW1;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE   AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN   Name=recA {ECO:0000255|HAMAP-Rule:MF_00268};
OS   Legionella pneumophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2121588; DOI=10.1111/j.1574-6968.1990.tb13983.x;
RA   Zhao X., Dreyfus L.A.;
RT   "Expression and nucleotide sequence analysis of the Legionella pneumophila
RT   recA gene.";
RL   FEMS Microbiol. Lett. 58:227-231(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43109 / NCTC 12008 / RC1 / Olda / Serogroup 1;
RX   PubMed=11251842; DOI=10.1111/j.1365-2958.2001.02314.x;
RA   Lueneberg E., Mayer B., Daryab N., Kooistra O., Zaehringer U., Rohde M.,
RA   Swanson J., Frosch M.;
RT   "Chromosomal insertion and excision of a 30 kb unstable genetic element is
RT   responsible for phase variation of lipopolysaccharide and other virulence
RT   determinants in Legionella pneumophila.";
RL   Mol. Microbiol. 39:1259-1271(2001).
CC   -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC       stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC       DNA, and the ATP-dependent hybridization of homologous single-stranded
CC       DNAs. It interacts with LexA causing its activation and leading to its
CC       autocatalytic cleavage. {ECO:0000255|HAMAP-Rule:MF_00268}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC   -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00268}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA39098.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X55453; CAA39097.1; -; Genomic_DNA.
DR   EMBL; X55453; CAA39098.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AJ277756; CAC33484.1; -; Genomic_DNA.
DR   PIR; A60989; A60989.
DR   RefSeq; WP_010947527.1; NZ_UGOV01000002.1.
DR   AlphaFoldDB; Q05358; -.
DR   SMR; Q05358; -.
DR   STRING; 91892.BIZ52_08625; -.
DR   GeneID; 66490933; -.
DR   eggNOG; COG0468; Bacteria.
DR   OrthoDB; 1080436at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd00983; recA; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00268; RecA; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013765; DNA_recomb/repair_RecA.
DR   InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR023400; RecA_C.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   PANTHER; PTHR45900; PTHR45900; 1.
DR   Pfam; PF00154; RecA; 1.
DR   PRINTS; PR00142; RECA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54752; SSF54752; 1.
DR   TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR   PROSITE; PS00321; RECA_1; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW   DNA-binding; Nucleotide-binding; SOS response.
FT   CHAIN           1..348
FT                   /note="Protein RecA"
FT                   /id="PRO_0000122740"
FT   BINDING         66..73
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
FT   CONFLICT        13
FT                   /note="V -> L (in Ref. 2; CAC33484)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   348 AA;  37935 MW;  1FB0B182FC41A035 CRC64;
     MEENKQKALS AAVSQIERQF GKGSVMRMGD STVSRDIEAI STGSLGLDIA LGIGGLPKGR
     IVEIYGPESS GKTTLTLQVI AECQKMGGTA AFIDAEHALD PSYAQKLGVK VDELLVSQPD
     TGEQALEITD MLVRSAAVDV VIIDSVAALT PKAEIEGEMG DSHVGLQARL MSQALRKLTA
     NIKRSNTLVI FINQIRMKIG VMFGSPETTT GGNALKFYAS VRLDIRRIGS IKKGEEILGS
     ETRVKVVKNK VAPPFKMTEF DILYNEGISR ESEIINLGVQ LNLIEKSGAW YSYKQEKIGQ
     GKENVRLYLK ENPQVAAELE QQIRTELLEK KLSVLASSSE DLFETIDD