RECA_MYCPU
ID RECA_MYCPU Reviewed; 339 AA.
AC P29226;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN Name=recA {ECO:0000255|HAMAP-Rule:MF_00268}; OrderedLocusNames=MYPU_2520;
OS Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX NCBI_TaxID=272635;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KD735;
RX PubMed=8112579; DOI=10.1016/0378-1119(94)90532-0;
RA King K.W., Woodard A., Dybvig K.;
RT "Cloning and characterization of the recA genes from Mycoplasma pulmonis
RT and M. mycoides subsp. mycoides.";
RL Gene 139:111-115(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAB CTIP;
RX PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT pulmonis.";
RL Nucleic Acids Res. 29:2145-2153(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 99-200.
RX PubMed=1556091; DOI=10.1128/jb.174.8.2729-2732.1992;
RA Dybvig K., Hollingshead S.K., Heath D.G., Clewell D.B., Sun F., Woodard A.;
RT "Degenerate oligonucleotide primers for enzymatic amplification of recA
RT sequences from Gram-positive bacteria and mycoplasmas.";
RL J. Bacteriol. 174:2729-2732(1992).
CC -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC DNA, and the ATP-dependent hybridization of homologous single-stranded
CC DNAs. It interacts with LexA causing its activation and leading to its
CC autocatalytic cleavage.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC Rule:MF_00268}.
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DR EMBL; L22074; AAA20406.1; -; Genomic_DNA.
DR EMBL; AL445563; CAC13425.1; -; Genomic_DNA.
DR EMBL; M81467; AAA25436.1; -; Genomic_DNA.
DR PIR; D41846; D41846.
DR PIR; D90543; D90543.
DR RefSeq; WP_010925056.1; NC_002771.1.
DR AlphaFoldDB; P29226; -.
DR SMR; P29226; -.
DR STRING; 272635.MYPU_2520; -.
DR EnsemblBacteria; CAC13425; CAC13425; CAC13425.
DR KEGG; mpu:MYPU_2520; -.
DR eggNOG; COG0468; Bacteria.
DR HOGENOM; CLU_040469_1_2_14; -.
DR OMA; DYGEQAL; -.
DR OrthoDB; 1080436at2; -.
DR BioCyc; MPUL272635:G1GT6-253-MON; -.
DR Proteomes; UP000000528; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd00983; recA; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00268; RecA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013765; DNA_recomb/repair_RecA.
DR InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR023400; RecA_C.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45900; PTHR45900; 1.
DR Pfam; PF00154; RecA; 1.
DR PRINTS; PR00142; RECA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54752; SSF54752; 1.
DR TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR PROSITE; PS00321; RECA_1; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT CHAIN 1..339
FT /note="Protein RecA"
FT /id="PRO_0000122766"
FT BINDING 73..80
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
SQ SEQUENCE 339 AA; 37190 MW; 7341979DD5AB1EB2 CRC64;
MSENNQSNQN NQINKIIKST IEEIEKKFGN ESIMLLGQKE KCDVDVFSSG SYAINSALGI
GGFPKGRIIE IFGPESSGKT TIALHTIAEI QKKNGFAAFI DVEHSIDPVY AKNLGIDIDN
LLISQPDSGE QALEIVDILA KSGSIDLIVV DSVAALVPEA ELNGEMKDQS IGLQARLMSK
ALRKITGSLS KNKTSVIFIN QVREKIGVVF GNPETTPGGR ALKFYASIRL DVRKSTNIML
NNDISGNQIR VKVVKNKLAP PFKIAETEII FSKGINKFGE VADLALVHDV LQKKGAWFSY
NGNNIAQGRQ KLIAQLESNN ELFEEIFQKI VEKENQKLS
