RECA_NEIMB
ID RECA_NEIMB Reviewed; 348 AA.
AC P0DH59; P49984; P56988;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN Name=recA {ECO:0000255|HAMAP-Rule:MF_00268}; OrderedLocusNames=NMB1445;
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58;
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H.,
RA Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M.,
RA Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297.
RC STRAIN=CCUG 23094 / S3446 / Serogroup B / Serotype 14,
RC HF116 / Serogroup Z / Serotype NT, HF130 / Serogroup B / Serotype NT,
RC N94II / Serogroup Y / Serotype NT, and
RC P63 / Serogroup B / Serotype NT / Subtype 2;
RX PubMed=1406254; DOI=10.1111/j.1365-2958.1992.tb01387.x;
RA Zhou J., Spratt B.G.;
RT "Sequence diversity within the argF, fbp and recA genes of natural isolates
RT of Neisseria meningitidis: interspecies recombination within the argF
RT gene.";
RL Mol. Microbiol. 6:2135-2146(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297.
RC STRAIN=CCUG 23094 / S3446 / Serogroup B / Serotype 14;
RX PubMed=8995060; DOI=10.1007/bf02202111;
RA Feil E., Zhou J., Maynard Smith J., Spratt B.G.;
RT "A comparison of the nucleotide sequences of the adk and recA genes of
RT pathogenic and commensal Neisseria species: evidence for extensive
RT interspecies recombination within adk.";
RL J. Mol. Evol. 43:631-640(1996).
CC -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC DNA, and the ATP-dependent hybridization of homologous single-stranded
CC DNAs. It interacts with LexA causing its activation and leading to its
CC autocatalytic cleavage. {ECO:0000255|HAMAP-Rule:MF_00268}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC Rule:MF_00268}.
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DR EMBL; AE002098; AAF41805.1; -; Genomic_DNA.
DR EMBL; X64843; CAA46055.1; -; Genomic_DNA.
DR EMBL; X64844; CAA46056.1; -; Genomic_DNA.
DR EMBL; X64845; CAA46057.1; -; Genomic_DNA.
DR EMBL; X64846; CAA46058.1; -; Genomic_DNA.
DR EMBL; X64848; CAA46060.1; -; Genomic_DNA.
DR EMBL; U57903; AAB49196.1; -; Genomic_DNA.
DR PIR; F81082; F81082.
DR PIR; S24745; S24745.
DR RefSeq; NP_274457.1; NC_003112.2.
DR RefSeq; WP_002213013.1; NC_003112.2.
DR AlphaFoldDB; P0DH59; -.
DR SMR; P0DH59; -.
DR STRING; 122586.NMB1445; -.
DR PaxDb; P0DH59; -.
DR EnsemblBacteria; AAF41805; AAF41805; NMB1445.
DR GeneID; 61281624; -.
DR KEGG; nme:NMB1445; -.
DR PATRIC; fig|122586.8.peg.1820; -.
DR HOGENOM; CLU_040469_3_2_4; -.
DR OMA; DYGEQAL; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd00983; recA; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00268; RecA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013765; DNA_recomb/repair_RecA.
DR InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR023400; RecA_C.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45900; PTHR45900; 1.
DR Pfam; PF00154; RecA; 1.
DR PRINTS; PR00142; RECA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54752; SSF54752; 1.
DR TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR PROSITE; PS00321; RECA_1; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT CHAIN 1..348
FT /note="Protein RecA"
FT /id="PRO_0000122778"
FT BINDING 66..73
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
FT VARIANT 138
FT /note="I -> V (in strain: P63)"
SQ SEQUENCE 348 AA; 37612 MW; A6597854E45D7BA5 CRC64;
MSDDKSKALA AALAQIEKSF GKGAIMKMDG SQQEENLEVI STGSLGLDLA LGVGGLPRGR
IVEIFGPESS GKTTLCLEAV AQCQKNGGVC AFVDAEHAFD PVYARKLGVK VEELYLSQPD
TGEQALEICD TLVRSGGIDM VVVDSVAALV PKAEIEGDMG DSHVGLQARL MSQALRKLTG
HIKKTNTLVV FINQIRMKIG VMFGSPETTT GGNALKFYSS VRLDIRRTGS IKKGEEVLGN
ETRVKVIKNK VAPPFRQAEF DILYGEGISW EGELIDIGVK NDIINKSGAW YSYNGAKIGQ
GKDNVRVWLK ENPEVANEID AKIRALNGVE MHITEGTQDE TDGERPEE
