RECA_PSEAE
ID RECA_PSEAE Reviewed; 346 AA.
AC P08280;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN Name=recA {ECO:0000255|HAMAP-Rule:MF_00268}; OrderedLocusNames=PA3617;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAO;
RX PubMed=2823059; DOI=10.1007/bf00328132;
RA Sano Y., Kageyama M.;
RT "The sequence and function of the recA gene and its protein in Pseudomonas
RT aeruginosa PAO.";
RL Mol. Gen. Genet. 208:412-419(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAM 7;
RA Zaitsev E.N., Krjukov V.M., Kuzmin N.P., Alekseev A.A., Lanzov V.A.;
RL Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2127886;
RA Kryukov V.M., Zaitsev E.N., Kouzmin N.P., Bayev A.A.;
RT "Structure of the Pseudomonas aeruginosa recA gene.";
RL Bioorg. Khim. 16:1177-1182(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PAO;
RX PubMed=8468303; DOI=10.1128/jb.175.8.2451-2454.1993;
RA Sano Y.;
RT "Role of the recA-related gene adjacent to the recA gene in Pseudomonas
RT aeruginosa.";
RL J. Bacteriol. 175:2451-2454(1993).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC DNA, and the ATP-dependent hybridization of homologous single-stranded
CC DNAs. It interacts with LexA causing its activation and leading to its
CC autocatalytic cleavage.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC Rule:MF_00268}.
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DR EMBL; X05691; CAA29173.1; -; Genomic_DNA.
DR EMBL; X52261; CAA36504.1; -; Genomic_DNA.
DR EMBL; D13090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AE004091; AAG07005.1; -; Genomic_DNA.
DR PIR; S06265; RQPSAA.
DR RefSeq; NP_252307.1; NC_002516.2.
DR RefSeq; WP_003092260.1; NZ_QZGE01000001.1.
DR AlphaFoldDB; P08280; -.
DR SMR; P08280; -.
DR STRING; 287.DR97_4322; -.
DR PaxDb; P08280; -.
DR PRIDE; P08280; -.
DR DNASU; 880173; -.
DR EnsemblBacteria; AAG07005; AAG07005; PA3617.
DR GeneID; 880173; -.
DR KEGG; pae:PA3617; -.
DR PATRIC; fig|208964.12.peg.3785; -.
DR PseudoCAP; PA3617; -.
DR HOGENOM; CLU_040469_3_2_6; -.
DR InParanoid; P08280; -.
DR OMA; EGARHMS; -.
DR PhylomeDB; P08280; -.
DR BioCyc; PAER208964:G1FZ6-3686-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd00983; recA; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00268; RecA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013765; DNA_recomb/repair_RecA.
DR InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR023400; RecA_C.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45900; PTHR45900; 1.
DR Pfam; PF00154; RecA; 1.
DR PRINTS; PR00142; RECA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54752; SSF54752; 1.
DR TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR PROSITE; PS00321; RECA_1; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT CHAIN 1..346
FT /note="Protein RecA"
FT /id="PRO_0000122801"
FT BINDING 65..72
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
FT CONFLICT 333
FT /note="V -> L (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 36879 MW; F43826566987FF28 CRC64;
MDENKKRALA AALGQIERQF GKGAVMRMGD HERQAIPAIS TGSLGLDIAL GIGGLPKGRI
VEIYGPESSG KTTLTLSVIA EAQKQGATCA FVDAEHALDP DYAGKLGVNV DDLLVSQPDT
GEQALEITDM LVRSNAVDVI IVDSVAALVP KAEIEGEMGD AHVGLQARLM SQALRKITGN
IKNANCLVIF INQIRMKIGV MFGNPETTTG GNALKFYASV RLDIRRTGAV KEGDEVVGSE
TRVKVVKNKV SPPFRQAEFQ ILYGKGIYRT GEIIDLGVQL GLVEKSGAWY SYQGSKIGQG
KANAAKYLED NPEIGSVLEK TIRDQLLAKS GPVKADAEEV ADAEAD
