ID   RECA_STAAU              Reviewed;         347 AA.
AC   P68845; Q02350;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE   AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN   Name=recA {ECO:0000255|HAMAP-Rule:MF_00268};
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8088537; DOI=10.1016/0378-1119(94)90033-7;
RA   Bayles K.W., Brunskill E.W., Iandolo J.J., Hruska L.L., Huang S.,
RA   Pattee P.A., Smiley B.K., Yasbin R.E.;
RT   "A genetic and molecular characterization of the recA gene from
RT   Staphylococcus aureus.";
RL   Gene 147:13-20(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bisognano C., Kelley W.L., Francois P., Lew D.P., Hooper D.C., Vaudaux P.;
RT   "Insertional inactivation of recA, but not agr or sar, abolishes increased
RT   adhesion to fibronectin evoked by sub-inhibitory levels of ciprofloxacin in
RT   quinolone resistant Staphylococcus aureus.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-204.
RC   STRAIN=ILRN450;
RX   PubMed=1629178; DOI=10.1128/jb.174.15.5171-5175.1992;
RA   Duwat P., Ehrlich S.D., Gruss A.;
RT   "A general method for cloning recA genes of Gram-positive bacteria by
RT   polymerase chain reaction.";
RL   J. Bacteriol. 174:5171-5175(1992).
CC   -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC       stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC       DNA, and the ATP-dependent hybridization of homologous single-stranded
CC       DNAs. It interacts with LexA causing its activation and leading to its
CC       autocatalytic cleavage.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC   -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00268}.
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DR   EMBL; L25893; AAA50463.1; -; Genomic_DNA.
DR   EMBL; AF317802; AAK15276.1; -; Genomic_DNA.
DR   EMBL; M94061; AAA26667.1; -; Genomic_DNA.
DR   PIR; F42721; F42721.
DR   RefSeq; WP_000368166.1; NZ_WYDB01000002.1.
DR   AlphaFoldDB; P68845; -.
DR   SMR; P68845; -.
DR   OMA; DYGEQAL; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd00983; recA; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00268; RecA; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013765; DNA_recomb/repair_RecA.
DR   InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR023400; RecA_C.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   PANTHER; PTHR45900; PTHR45900; 1.
DR   Pfam; PF00154; RecA; 1.
DR   PRINTS; PR00142; RECA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54752; SSF54752; 1.
DR   TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR   PROSITE; PS00321; RECA_1; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW   DNA-binding; Nucleotide-binding; SOS response.
FT   CHAIN           1..347
FT                   /note="Protein RecA"
FT                   /id="PRO_0000122843"
FT   REGION          325..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         65..72
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
SQ   SEQUENCE   347 AA;  37657 MW;  3A0C9B1A2E8CAFCF CRC64;
     MDNDRQKALD TVIKNMEKSF GKGAVMKLGD NIGRRVSTTS TGSVTLDNAL GVGGYPKGRI
     IEIYGPESSG KTTVALHAIA EVQSNGGVAA FIDAEHALDP EYAQALGVDI DNLYLSQPDH
     GEQGLEIAEA FVRSGAVDIV VVDSVAALTP KAEIEGEMGD THVGLQARLM SQALRKLSGA
     ISKSNTTAIF INQIREKVGV MFGNPETTPG GRALKFYSSV RLEVRRAEQL KQGQEIVGNR
     TKIKVVKNKV APPFRVAEVD IMYGQGISKE GELIDLGVEN DIVDKSGAWY SYNGERMGQG
     KENVKMYLKE NPQIKEEIDR KLREKLGISD GDVEETEDAP KSLFDEE