RECA_THEMA
ID RECA_THEMA Reviewed; 356 AA.
AC P36203;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN Name=recA {ECO:0000255|HAMAP-Rule:MF_00268}; OrderedLocusNames=TM_1859;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7929298; DOI=10.1016/s0021-9258(18)47335-8;
RA Wetmur J.G., Wong D.M., Ortiz B., Tong J., Reichert F., Gelfand D.H.;
RT "Cloning, sequencing, and expression of RecA proteins from three distantly
RT related thermophilic eubacteria.";
RL J. Biol. Chem. 269:25928-25935(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC DNA, and the ATP-dependent hybridization of homologous single-stranded
CC DNAs. It interacts with LexA causing its activation and leading to its
CC autocatalytic cleavage. {ECO:0000255|HAMAP-Rule:MF_00268}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC Rule:MF_00268}.
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DR EMBL; L23425; AAA27417.1; -; Genomic_DNA.
DR EMBL; AE000512; AAD36921.1; -; Genomic_DNA.
DR PIR; D55020; D55020.
DR RefSeq; NP_229655.1; NC_000853.1.
DR RefSeq; WP_004082410.1; NZ_CP011107.1.
DR PDB; 3HR8; X-ray; 1.95 A; A=1-356.
DR PDBsum; 3HR8; -.
DR AlphaFoldDB; P36203; -.
DR SMR; P36203; -.
DR STRING; 243274.THEMA_04875; -.
DR EnsemblBacteria; AAD36921; AAD36921; TM_1859.
DR KEGG; tma:TM1859; -.
DR eggNOG; COG0468; Bacteria.
DR InParanoid; P36203; -.
DR OMA; DYGEQAL; -.
DR OrthoDB; 1080436at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd00983; recA; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00268; RecA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013765; DNA_recomb/repair_RecA.
DR InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR023400; RecA_C.
DR InterPro; IPR020587; RecA_monomer-monomer_interface.
DR PANTHER; PTHR45900; PTHR45900; 1.
DR Pfam; PF00154; RecA; 1.
DR PRINTS; PR00142; RECA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54752; SSF54752; 1.
DR TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR PROSITE; PS00321; RECA_1; 1.
DR PROSITE; PS50162; RECA_2; 1.
DR PROSITE; PS50163; RECA_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cytoplasm; DNA damage; DNA recombination;
KW DNA repair; DNA-binding; Nucleotide-binding; Reference proteome;
KW SOS response.
FT CHAIN 1..356
FT /note="Protein RecA"
FT /id="PRO_0000122878"
FT BINDING 68..75
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
FT HELIX 5..22
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 47..52
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 54..59
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 62..69
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 74..87
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 92..98
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 103..109
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 113..115
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 117..119
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 124..136
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 141..146
FT /evidence="ECO:0007829|PDB:3HR8"
FT TURN 148..150
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 154..157
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 168..185
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 190..199
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 201..205
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 213..220
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 222..235
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 238..254
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 259..265
FT /evidence="ECO:0007829|PDB:3HR8"
FT TURN 266..268
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 272..282
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 285..289
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 292..296
FT /evidence="ECO:0007829|PDB:3HR8"
FT STRAND 302..307
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 308..318
FT /evidence="ECO:0007829|PDB:3HR8"
FT HELIX 320..333
FT /evidence="ECO:0007829|PDB:3HR8"
SQ SEQUENCE 356 AA; 38798 MW; A2B70853C26C95FD CRC64;
MPEEKQKKSV LEKALKRIEE NFGKGSIMIL GDETQVQPVE VIPTGSLAID IATGVGGYPR
GRIVEIFGQE SSGKTTLALH AIAEAQKMGG VAAFIDAEHA LDPVYAKNLG VDLKSLLISQ
PDHGEQALEI VDELVRSGVV DLIVVDSVAA LVPRAEIEGA MGDMQVGLQA RLMSQALRKI
AGSVNKSKAV VIFTNQIRMK IGVMFGSPET TTGGLALKFY ATMRMEVRRG EPIKEGKDVI
GNVISVKIVK NKVAPPFKTA QTYIIYGKGI DREYELFNIA VNEGIVDRKG SWYYYTTLKG
EEVSLGQGSS NAVQFLKDNP EIAGEIERRI REKYGLLSVE KEEQRKEKKS SGEEAS
