ID   RECA_THET8              Reviewed;         340 AA.
AC   Q5SHB2;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Protein RecA {ECO:0000255|HAMAP-Rule:MF_00268};
DE   AltName: Full=Recombinase A {ECO:0000255|HAMAP-Rule:MF_00268};
GN   Name=recA {ECO:0000255|HAMAP-Rule:MF_00268}; OrderedLocusNames=TTHA1818;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8138553; DOI=10.1093/oxfordjournals.jbchem.a124278;
RA   Kato R., Kuramitsu S.;
RT   "RecA protein from an extremely thermophilic bacterium, Thermus
RT   thermophilus HB8.";
RL   J. Biochem. 114:926-929(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8;
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of single-
CC       stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex
CC       DNA, and the ATP-dependent hybridization of homologous single-stranded
CC       DNAs. It interacts with LexA causing its activation and leading to its
CC       autocatalytic cleavage.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00268}.
CC   -!- SIMILARITY: Belongs to the RecA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00268}.
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DR   EMBL; D17392; BAA04215.1; -; Genomic_DNA.
DR   EMBL; AP008226; BAD71641.1; -; Genomic_DNA.
DR   RefSeq; WP_011228937.1; NC_006461.1.
DR   RefSeq; YP_145084.1; NC_006461.1.
DR   AlphaFoldDB; Q5SHB2; -.
DR   SMR; Q5SHB2; -.
DR   STRING; 300852.55773200; -.
DR   EnsemblBacteria; BAD71641; BAD71641; BAD71641.
DR   GeneID; 3168508; -.
DR   KEGG; ttj:TTHA1818; -.
DR   PATRIC; fig|300852.9.peg.1789; -.
DR   eggNOG; COG0468; Bacteria.
DR   HOGENOM; CLU_040469_3_2_0; -.
DR   OMA; DYGEQAL; -.
DR   PhylomeDB; Q5SHB2; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   CDD; cd00983; recA; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00268; RecA; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013765; DNA_recomb/repair_RecA.
DR   InterPro; IPR020584; DNA_recomb/repair_RecA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR023400; RecA_C.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   PANTHER; PTHR45900; PTHR45900; 1.
DR   Pfam; PF00154; RecA; 1.
DR   PRINTS; PR00142; RECA.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54752; SSF54752; 1.
DR   TIGRFAMs; TIGR02012; tigrfam_recA; 1.
DR   PROSITE; PS00321; RECA_1; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA recombination; DNA repair;
KW   DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT   CHAIN           1..340
FT                   /note="Protein RecA"
FT                   /id="PRO_0000122881"
FT   BINDING         65..72
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00268"
SQ   SEQUENCE   340 AA;  36385 MW;  53F4A4A2F54B2BD4 CRC64;
     MDESKRKALE NALKAIEKEF GKGAVMRLGE MPKQQVDVIP TGSLALDLAL GIGGIPRGRI
     VEIYGPESGG KTTLALTIIA QAQRRGGVAA FVDAEHALDP LYAQRLGVQV EDLLVSQPDT
     GEQALEIVEL LARSGAVDVI VVDSVAALVP RAEIEGEMGD QHVGLQARLM SQALRKLTAV
     LAKSNTAAIF INQVREKVGV TYGNPETTPG GRALKFYASV RLDVRKSGQP IKVGNEAVGV
     KVRVKVVKNK LAPPFREAEL EIYFGRGLDP VADLVNVAVA AGVIEKAGSW FSYGELRLGQ
     GKEKAAEALR ERPELLEEIR AKVLERSDQV VLAAGEDEGE