ID   RECF_CLOD6              Reviewed;         371 AA.
AC   Q18C86;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA replication and repair protein RecF {ECO:0000255|HAMAP-Rule:MF_00365};
GN   Name=recF {ECO:0000255|HAMAP-Rule:MF_00365}; OrderedLocusNames=CD630_00040;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC       required for DNA replication and normal SOS inducibility. RecF binds
CC       preferentially to single-stranded, linear DNA. It also seems to bind
CC       ATP. {ECO:0000255|HAMAP-Rule:MF_00365}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00365}.
CC   -!- SIMILARITY: Belongs to the RecF family. {ECO:0000255|HAMAP-
CC       Rule:MF_00365}.
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DR   EMBL; AM180355; CAJ66818.1; -; Genomic_DNA.
DR   RefSeq; WP_003429303.1; NZ_CP010905.2.
DR   RefSeq; YP_001086467.1; NC_009089.1.
DR   AlphaFoldDB; Q18C86; -.
DR   SMR; Q18C86; -.
DR   STRING; 272563.CD630_00040; -.
DR   EnsemblBacteria; CAJ66818; CAJ66818; CD630_00040.
DR   GeneID; 66352442; -.
DR   KEGG; cdf:CD630_00040; -.
DR   KEGG; pdc:CDIF630_00004; -.
DR   PATRIC; fig|272563.120.peg.4; -.
DR   eggNOG; COG1195; Bacteria.
DR   OMA; GESWSYA; -.
DR   PhylomeDB; Q18C86; -.
DR   BioCyc; PDIF272563:G12WB-4-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1050.90; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00365; RecF; 1.
DR   InterPro; IPR001238; DNA-binding_RecF.
DR   InterPro; IPR018078; DNA-binding_RecF_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR042174; RecF_2.
DR   PANTHER; PTHR32182:SF0; PTHR32182:SF0; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00611; recf; 1.
DR   PROSITE; PS00617; RECF_1; 1.
DR   PROSITE; PS00618; RECF_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT   CHAIN           1..371
FT                   /note="DNA replication and repair protein RecF"
FT                   /id="PRO_1000048512"
FT   BINDING         30..37
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00365"
SQ   SEQUENCE   371 AA;  42916 MW;  2AB3C01BB1E11790 CRC64;
     MKLKSLQLVN FRNYKKLHLE FNGKVNLLVG KNGQGKTNIV ESIYMLSFGK SFRTNKDKEM
     VRFNSENLYI GGSFSKYNKY SLIELIIGKD KKGIRINKVP LQKIQELLGN LNVVIFSPED
     LRLVKEGPKE RRAFIDKEIS QIIPKYYKYL TNYNKTLSQR SRVLKNIHVD EALLDVYDDT
     LAKYGSYIYI LRRDFIKKIA NISENMHMNL TNGVERLSIR YKNQINITDE DTIDTVYNKF
     LAKLSSNRPN DIESKTTRYG IHKDDLNIFI NDLDARLFGS QGQQRTASIS LKLSEIELIK
     NEVEEYPVLI LDDVFSELDE ARQKLLVNNL SNVQMFITSA EVSHKKIFDE KNVTIFNIEN
     GDVISIENGG N