RECF_LACLA
ID RECF_LACLA Reviewed; 358 AA.
AC Q9CE70; P50925;
DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT 04-MAY-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=DNA replication and repair protein RecF;
GN Name=recF; OrderedLocusNames=LL1975; ORFNames=L0261;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 7962;
RX PubMed=8621080; DOI=10.1016/0378-1119(96)81421-1;
RA MacCormick C.A., Griffin H.G., Gasson M.J.;
RT "Sequence of a Lactococcus lactis DNA fragment homologous to the recF gene
RT of Bacillus subtilis.";
RL Gene 170:151-152(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC required for DNA replication and normal SOS inducibility. RecF binds
CC preferentially to single-stranded, linear DNA. It also seems to bind
CC ATP (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RecF family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X89367; CAA61549.1; -; Genomic_DNA.
DR EMBL; AE005176; AAK06073.1; -; Genomic_DNA.
DR PIR; G86871; G86871.
DR PIR; JC4753; JC4753.
DR RefSeq; NP_268132.1; NC_002662.1.
DR RefSeq; WP_010906242.1; NC_002662.1.
DR AlphaFoldDB; Q9CE70; -.
DR SMR; Q9CE70; -.
DR STRING; 272623.L0261; -.
DR PaxDb; Q9CE70; -.
DR PRIDE; Q9CE70; -.
DR EnsemblBacteria; AAK06073; AAK06073; L0261.
DR GeneID; 60356563; -.
DR KEGG; lla:L0261; -.
DR PATRIC; fig|272623.7.peg.2127; -.
DR eggNOG; COG1195; Bacteria.
DR HOGENOM; CLU_040267_0_1_9; -.
DR OMA; GESWSYA; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1050.90; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00365; RecF; 1.
DR InterPro; IPR001238; DNA-binding_RecF.
DR InterPro; IPR018078; DNA-binding_RecF_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR042174; RecF_2.
DR PANTHER; PTHR32182:SF0; PTHR32182:SF0; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00611; recf; 1.
DR PROSITE; PS00617; RECF_1; 1.
DR PROSITE; PS00618; RECF_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT CHAIN 1..358
FT /note="DNA replication and repair protein RecF"
FT /id="PRO_0000196422"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VARIANT 74
FT /note="V -> G (in strain: ATCC 7962)"
FT VARIANT 81
FT /note="V -> I (in strain: ATCC 7962)"
FT VARIANT 291
FT /note="F -> L (in strain: ATCC 7962)"
SQ SEQUENCE 358 AA; 41356 MW; AB5004F5318AC568 CRC64;
MKLKAIELKN FRNYEELKLD FHPNLNIFLG QNAQGKTNIL EAIHFLALTR SHRTSHDKEL
ISWSQQEMKV SGVVEKAHAT VPLEVQLSPK GRIAKANHLK ENRLADYIGQ LKILMFAPEN
LELVKGSPAT RRKFMDIELG QIHAVYLYDS MRYNRALKER NAYLKFDKDK IDKNFLSVLD
GQLAEHGNKI MLERQNFIDK LEVHAKKIHE QLTHGKENLK IIYNQNVKTD FSKELLSRQD
HDIFRHQTSV GPHRDDLQFF INEINVADFG SQGQQRTVAL SIKLAEIDLI FEETGEYPIL
LLDDVMSELD NHRQLDLIET SLGKTQTFIT TTTLDHLKNL PENLSIFHVN AGTIEQEQ