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RECF_LACLA
ID   RECF_LACLA              Reviewed;         358 AA.
AC   Q9CE70; P50925;
DT   04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT   04-MAY-2001, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=DNA replication and repair protein RecF;
GN   Name=recF; OrderedLocusNames=LL1975; ORFNames=L0261;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 7962;
RX   PubMed=8621080; DOI=10.1016/0378-1119(96)81421-1;
RA   MacCormick C.A., Griffin H.G., Gasson M.J.;
RT   "Sequence of a Lactococcus lactis DNA fragment homologous to the recF gene
RT   of Bacillus subtilis.";
RL   Gene 170:151-152(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC       required for DNA replication and normal SOS inducibility. RecF binds
CC       preferentially to single-stranded, linear DNA. It also seems to bind
CC       ATP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RecF family. {ECO:0000305}.
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DR   EMBL; X89367; CAA61549.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK06073.1; -; Genomic_DNA.
DR   PIR; G86871; G86871.
DR   PIR; JC4753; JC4753.
DR   RefSeq; NP_268132.1; NC_002662.1.
DR   RefSeq; WP_010906242.1; NC_002662.1.
DR   AlphaFoldDB; Q9CE70; -.
DR   SMR; Q9CE70; -.
DR   STRING; 272623.L0261; -.
DR   PaxDb; Q9CE70; -.
DR   PRIDE; Q9CE70; -.
DR   EnsemblBacteria; AAK06073; AAK06073; L0261.
DR   GeneID; 60356563; -.
DR   KEGG; lla:L0261; -.
DR   PATRIC; fig|272623.7.peg.2127; -.
DR   eggNOG; COG1195; Bacteria.
DR   HOGENOM; CLU_040267_0_1_9; -.
DR   OMA; GESWSYA; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1050.90; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00365; RecF; 1.
DR   InterPro; IPR001238; DNA-binding_RecF.
DR   InterPro; IPR018078; DNA-binding_RecF_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR042174; RecF_2.
DR   PANTHER; PTHR32182:SF0; PTHR32182:SF0; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00611; recf; 1.
DR   PROSITE; PS00617; RECF_1; 1.
DR   PROSITE; PS00618; RECF_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT   CHAIN           1..358
FT                   /note="DNA replication and repair protein RecF"
FT                   /id="PRO_0000196422"
FT   BINDING         30..37
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VARIANT         74
FT                   /note="V -> G (in strain: ATCC 7962)"
FT   VARIANT         81
FT                   /note="V -> I (in strain: ATCC 7962)"
FT   VARIANT         291
FT                   /note="F -> L (in strain: ATCC 7962)"
SQ   SEQUENCE   358 AA;  41356 MW;  AB5004F5318AC568 CRC64;
     MKLKAIELKN FRNYEELKLD FHPNLNIFLG QNAQGKTNIL EAIHFLALTR SHRTSHDKEL
     ISWSQQEMKV SGVVEKAHAT VPLEVQLSPK GRIAKANHLK ENRLADYIGQ LKILMFAPEN
     LELVKGSPAT RRKFMDIELG QIHAVYLYDS MRYNRALKER NAYLKFDKDK IDKNFLSVLD
     GQLAEHGNKI MLERQNFIDK LEVHAKKIHE QLTHGKENLK IIYNQNVKTD FSKELLSRQD
     HDIFRHQTSV GPHRDDLQFF INEINVADFG SQGQQRTVAL SIKLAEIDLI FEETGEYPIL
     LLDDVMSELD NHRQLDLIET SLGKTQTFIT TTTLDHLKNL PENLSIFHVN AGTIEQEQ
 
 
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