ID   RECF_MYCLE              Reviewed;         385 AA.
AC   P46391;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 3.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=DNA replication and repair protein RecF;
GN   Name=recF; OrderedLocusNames=ML0003;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Fsihi H., Salazar L., Takiff H.E., Cole S.T.;
RL   Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-223.
RX   PubMed=8969512; DOI=10.1099/13500872-142-11-3147;
RA   Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G.,
RA   Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.;
RT   "Gene arrangement and organization in an approximately 76 kb fragment
RT   encompassing the oriC region of the chromosome of Mycobacterium leprae.";
RL   Microbiology 142:3147-3161(1996).
CC   -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC       required for DNA replication and normal SOS inducibility. RecF binds
CC       preferentially to single-stranded, linear DNA. It also seems to bind
CC       ATP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RecF family. {ECO:0000305}.
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DR   EMBL; Z70722; CAA94710.1; -; Genomic_DNA.
DR   EMBL; AL583917; CAC29511.1; -; Genomic_DNA.
DR   EMBL; L39923; AAB53143.1; -; Genomic_DNA.
DR   PIR; C86909; C86909.
DR   PIR; T10003; T10003.
DR   RefSeq; NP_301131.1; NC_002677.1.
DR   RefSeq; WP_010907456.1; NC_002677.1.
DR   AlphaFoldDB; P46391; -.
DR   SMR; P46391; -.
DR   STRING; 272631.ML0003; -.
DR   EnsemblBacteria; CAC29511; CAC29511; CAC29511.
DR   KEGG; mle:ML0003; -.
DR   PATRIC; fig|272631.5.peg.3; -.
DR   Leproma; ML0003; -.
DR   eggNOG; COG1195; Bacteria.
DR   HOGENOM; CLU_040267_1_1_11; -.
DR   OMA; GESWSYA; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1050.90; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00365; RecF; 1.
DR   InterPro; IPR001238; DNA-binding_RecF.
DR   InterPro; IPR018078; DNA-binding_RecF_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR042174; RecF_2.
DR   PANTHER; PTHR32182:SF0; PTHR32182:SF0; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00611; recf; 1.
DR   PROSITE; PS00617; RECF_1; 1.
DR   PROSITE; PS00618; RECF_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT   CHAIN           1..385
FT                   /note="DNA replication and repair protein RecF"
FT                   /id="PRO_0000196432"
FT   BINDING         30..37
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        162
FT                   /note="T -> L (in Ref. 1; CAA94710)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        221
FT                   /note="P -> T (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   385 AA;  42067 MW;  3EE309D7DA976D8B CRC64;
     MYVRHFGLRD FRSWDHVDLE LNPGRTVFFG PNGNGKTNLI EALWYSTTLS SHRVGTDIPL
     IRAGTIRAIV STIVVNEGRE CAIDLEIAAG RANRARLNRS LVRGMREVVG VLRAVLFAPE
     DLALVCGDPA NRRRYLDDLA TVRQPVIAAV RADYDKVLRQ RTALLKSLAA ARYRSDQGVL
     DTLDVWDTRL AEHGAELMAA RIDLVNQLAP EVEKAYQLLA PGSRTASISY RASLDIGGIA
     GVGSSDRALL QADLLAGLST RRNVELERGI CLVGPHRDEL ELRLGDQPAK GFASHGESWS
     LAIALRLAAY ELLRADGNEP VLLLDDVFAE LDAARCRALA TVAESAEQVL VTSAAQEDIP
     VGWDAKWVTV DLRDSDSGRV SVVYP