RECF_SALTY
ID RECF_SALTY Reviewed; 357 AA.
AC P24900;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=DNA replication and repair protein RecF;
GN Name=recF; OrderedLocusNames=STM3836;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1542576; DOI=10.1093/nar/20.4.839;
RA Sandler S.J., Chackerian B., Li J.T., Clark A.J.;
RT "Sequence and complementation analysis of recF genes from Escherichia coli,
RT Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence
RT for an essential phosphate binding loop.";
RL Nucleic Acids Res. 20:839-845(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC required for DNA replication and normal SOS inducibility. RecF binds
CC preferentially to single-stranded, linear DNA. It also seems to bind
CC ATP (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RecF family. {ECO:0000305}.
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DR EMBL; X62505; CAA44366.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL22695.1; -; Genomic_DNA.
DR PIR; S21057; S21057.
DR RefSeq; NP_462736.1; NC_003197.2.
DR RefSeq; WP_000060085.1; NC_003197.2.
DR AlphaFoldDB; P24900; -.
DR SMR; P24900; -.
DR STRING; 99287.STM3836; -.
DR PaxDb; P24900; -.
DR EnsemblBacteria; AAL22695; AAL22695; STM3836.
DR GeneID; 1255363; -.
DR KEGG; stm:STM3836; -.
DR PATRIC; fig|99287.12.peg.4063; -.
DR HOGENOM; CLU_040267_0_0_6; -.
DR OMA; GESWSYA; -.
DR PhylomeDB; P24900; -.
DR BioCyc; SENT99287:STM3836-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0000731; P:DNA synthesis involved in DNA repair; IBA:GO_Central.
DR GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1050.90; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00365; RecF; 1.
DR InterPro; IPR001238; DNA-binding_RecF.
DR InterPro; IPR018078; DNA-binding_RecF_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR042174; RecF_2.
DR PANTHER; PTHR32182:SF0; PTHR32182:SF0; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00611; recf; 1.
DR PROSITE; PS00617; RECF_1; 1.
DR PROSITE; PS00618; RECF_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..357
FT /note="DNA replication and repair protein RecF"
FT /id="PRO_0000196452"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 31..33
FT /note="ANG -> PNA (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 107..108
FT /note="EL -> DV (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="N -> T (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="R -> A (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 258..260
FT /note="IRA -> MLC (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="E -> Q (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="Missing (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="D -> A (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="A -> G (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
FT CONFLICT 331..333
FT /note="AIS -> EL (in Ref. 1; CAA44366)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 40514 MW; AD3555E649A2B46A CRC64;
MSLTRLLIKD FRNIENADLA LSPGFNFLVG ANGSGKTSVL EAIYTLGHGR AFRSLQPGRV
IRHEQEAFVL HGRLQSEERE TSIGLTKDKQ GDSKVRIDGT DGHKIAELAH LMPMQLITPE
GFTLLNGGPK YRRAFLDWGC FHNEAGFFTA WSNLKRLLKQ RNAALRQVSR YEQLRPWDKE
LIPLAEQIST WRAEYSSAIA QDMADTCQQF LPEFSLTFSF QRGWEKETDY ADVLERSFER
DRMLTYTAHG PHKADFRIRA DGAPVEDTLS RGQLKLLMCA LRLAQGEFLT RESGRRCLYL
IDDFASELDD ARRGLLASRL KATQSQVFVS AISAEHVIDM SDENSKMFTV EKGKITD
