RECF_STRP6
ID RECF_STRP6 Reviewed; 368 AA.
AC Q5X9A5; P49999;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=DNA replication and repair protein RecF {ECO:0000255|HAMAP-Rule:MF_00365};
GN Name=recF {ECO:0000255|HAMAP-Rule:MF_00365}; OrderedLocusNames=M6_Spy1873;
OS Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=286636;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 21547 / S43 / Serotype M6;
RX PubMed=7737521; DOI=10.1016/0378-1119(95)00069-i;
RA Deangelis P.L., Yang N., Weigel P.H.;
RT "Molecular cloning of the gene encoding RecF, a DNA repair enzyme, from
RT Streptococcus pyogenes.";
RL Gene 156:89-91(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-946 / MGAS10394;
RX PubMed=15272401; DOI=10.1086/422697;
RA Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT "Progress toward characterization of the group A Streptococcus metagenome:
RT complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL J. Infect. Dis. 190:727-738(2004).
CC -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC required for DNA replication and normal SOS inducibility. RecF binds
CC preferentially to single-stranded, linear DNA. It also seems to bind
CC ATP. {ECO:0000255|HAMAP-Rule:MF_00365}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00365}.
CC -!- SIMILARITY: Belongs to the RecF family. {ECO:0000255|HAMAP-
CC Rule:MF_00365}.
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DR EMBL; U07342; AAA85783.1; -; Genomic_DNA.
DR EMBL; CP000003; AAT88008.1; -; Genomic_DNA.
DR PIR; JC4077; JC4077.
DR RefSeq; WP_011185108.1; NC_006086.1.
DR AlphaFoldDB; Q5X9A5; -.
DR SMR; Q5X9A5; -.
DR EnsemblBacteria; AAT88008; AAT88008; M6_Spy1873.
DR KEGG; spa:M6_Spy1873; -.
DR HOGENOM; CLU_040267_0_1_9; -.
DR OMA; GESWSYA; -.
DR Proteomes; UP000001167; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1050.90; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00365; RecF; 1.
DR InterPro; IPR001238; DNA-binding_RecF.
DR InterPro; IPR018078; DNA-binding_RecF_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR042174; RecF_2.
DR PANTHER; PTHR32182:SF0; PTHR32182:SF0; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00611; recf; 1.
DR PROSITE; PS00617; RECF_1; 1.
DR PROSITE; PS00618; RECF_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW DNA-binding; Nucleotide-binding; SOS response.
FT CHAIN 1..368
FT /note="DNA replication and repair protein RecF"
FT /id="PRO_0000196476"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00365"
SQ SEQUENCE 368 AA; 41796 MW; EBF66F126C39D838 CRC64;
MWIKELELKH YRNYDHLLAS FSSGLNVFIG NNAQGKTNFL EAIYFLSLTR SHRTRADKEL
IHFDHSTVSL TGKIQRISGT VDLEINLSDK GRVTKINALK QAKLSDYIGT MMVVLFAPED
LQLVKGAPSL RRKFIDIDLG QIKPVYLSEL SHYNHVLKQR NSYLKSAQQI DAAFLAVLDE
QLAGYGARVM EHRIDFINAL EKEANTHHQA ISNGLESLSL SYQSSVVFDK KTNIYQQFLH
QLEKNHQKDF FRKNTSVGPH RDDLAFYING MNANFASQGQ HRSLILSLKM AEVSLMKALT
GDNPILLLDD VMSELDNTRQ TKLLETVIKE NVQTFITTTS LDHLSQLPEG IRIFHVTKGT
VQIDSDIH