ID   RECF_TREPA              Reviewed;         352 AA.
AC   O83049;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   04-MAY-2001, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA replication and repair protein RecF;
GN   Name=recF; OrderedLocusNames=TP_0003;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: The RecF protein is involved in DNA metabolism; it is
CC       required for DNA replication and normal SOS inducibility. RecF binds
CC       preferentially to single-stranded, linear DNA. It also seems to bind
CC       ATP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RecF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC65001.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000520; AAC65001.1; ALT_INIT; Genomic_DNA.
DR   PIR; B71378; B71378.
DR   AlphaFoldDB; O83049; -.
DR   SMR; O83049; -.
DR   STRING; 243276.TPANIC_0003; -.
DR   EnsemblBacteria; AAC65001; AAC65001; TP_0003.
DR   KEGG; tpa:TP_0003; -.
DR   eggNOG; COG1195; Bacteria.
DR   HOGENOM; CLU_040267_0_1_12; -.
DR   OMA; GESWSYA; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1050.90; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00365; RecF; 1.
DR   InterPro; IPR001238; DNA-binding_RecF.
DR   InterPro; IPR018078; DNA-binding_RecF_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR042174; RecF_2.
DR   PANTHER; PTHR32182:SF0; PTHR32182:SF0; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00611; recf; 1.
DR   PROSITE; PS00617; RECF_1; 1.
DR   PROSITE; PS00618; RECF_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-binding; Nucleotide-binding; Reference proteome; SOS response.
FT   CHAIN           1..352
FT                   /note="DNA replication and repair protein RecF"
FT                   /id="PRO_0000196482"
FT   BINDING         25..32
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   352 AA;  41216 MW;  22E8B8084CD30DCC CRC64;
     MTAINFRNLA HHTIDISSPE VFFVGNNGQG KTNILEVLYL AAYGNSFRTR TESELYATHA
     RSNEYRVKVM YRGEYTHTVQ IFSKNGKKRI EKNLKKIRTK KELISSIPCI LFFHNDLDFV
     VGTPERRRFF LDQSLSMCNP LYLEYLQKYH ALTKTKNREI KEKRVQLLDA LDTQIATVGF
     DLVQWRTQLV RDFNVIFTKY YERLGDLAQV RIEYKPSWSD SSVEEIVHSL YKRRKHDLAM
     GMSMSGPHRD KIHFTRSQAL FIPQASTGQR RLVSLVLRMS QAVFYTGVTG KLPVLLMDDV
     LLELDPEKRE RFMMSLPPYD QLFCTFLPGE AYRRYGREKT RVYFVSEGAC HE