ID   RECG_HAEIN              Reviewed;         693 AA.
AC   P43809;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=ATP-dependent DNA helicase RecG;
DE            EC=3.6.4.12;
GN   Name=recG; OrderedLocusNames=HI_1740;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC       Holliday junction intermediates to mature products by catalyzing branch
CC       migration. Has a DNA unwinding activity characteristic of a DNA
CC       helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC       DNA) (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC23387.1; -; Genomic_DNA.
DR   PIR; E64139; E64139.
DR   RefSeq; NP_439884.1; NC_000907.1.
DR   RefSeq; WP_005693902.1; NC_000907.1.
DR   AlphaFoldDB; P43809; -.
DR   SMR; P43809; -.
DR   STRING; 71421.HI_1740; -.
DR   EnsemblBacteria; AAC23387; AAC23387; HI_1740.
DR   KEGG; hin:HI_1740; -.
DR   PATRIC; fig|71421.8.peg.1823; -.
DR   eggNOG; COG1200; Bacteria.
DR   HOGENOM; CLU_005122_7_1_6; -.
DR   OMA; DNGFQAC; -.
DR   PhylomeDB; P43809; -.
DR   BioCyc; HINF71421:G1GJ1-1763-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR045562; RecG_dom3_C.
DR   InterPro; IPR033454; RecG_wedge.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF19833; RecG_C; 1.
DR   Pfam; PF17191; RecG_wedge; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00643; recG; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..693
FT                   /note="ATP-dependent DNA helicase RecG"
FT                   /id="PRO_0000102142"
FT   DOMAIN          283..448
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          482..628
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           397..400
FT                   /note="DEQH box"
FT   BINDING         296..303
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   693 AA;  78086 MW;  12D1BC65F0259950 CRC64;
     MSLELLDAVP LTSLSGVGAA ISNKLAKIGI HNLQDLLFHL PIRYEDRTRI TLIANLRPEQ
     YFTIEGIVQT CEVAFGRRPI LSVSLSDGTS KIMLRFFNFN AGMRNSFQVG VRVKAFGEVK
     RGRHMPEIHH PEYQIVRDNA PIVLEETLTP IYSTTEGLKQ NSLRKLTDQA LALLDKVQIA
     EILPNEFNPH QYSLKEALRL LHRPPPDISL EMLEQGKHPA QQRLIFEELL AHNLAMQKVR
     LGTQQFSALP LHYQTDLKQR FLATLPFQPT NAQKRVVSDI EQDLIKDYPM MRLVQGDVGS
     GKTLVAALAA LTAIDNGKQV ALMAPTEILA EQHANNFRRW FKPFGIEVGW LAGKVKGKSR
     QAELEKIKTG AVQMVVGTHA LFQEEVEFSD LALVIIDEQH RFGVHQRLML REKGEKAGFY
     PHQLIMTATP IPRTLAMTVY ADLDTSIIDE LPPGRTPITT VVVSEERRAE IVMRVKNACV
     NEKRQAYWVC TLIDESEVLE AQAAEAIWED LTKALPMLNI GLVHGRMKPQ EKQDVMMRFK
     NAELDLLVAT TVIEVGVDVP NASLMIIENA ERLGLSQLHQ LRGRVGRGCT ASFCVLMYKP
     PLGKVSQKRL QVLRDSQDGF VISEKDLEIR GPGEVLGTKQ TGIAELRVAN LMRDRKMIPT
     VQHYAKSLIQ KYPDVAESLI RRWLNNKEIY SNA