ID   RECG_HELPJ              Reviewed;         623 AA.
AC   Q9ZJA1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=ATP-dependent DNA helicase RecG;
DE            EC=3.6.4.12;
GN   Name=recG; OrderedLocusNames=jhp_1412;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC       Holliday junction intermediates to mature products by catalyzing branch
CC       migration. Has a DNA unwinding activity characteristic of a DNA
CC       helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC       DNA) (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE001439; AAD06990.1; -; Genomic_DNA.
DR   PIR; G71810; G71810.
DR   RefSeq; WP_010882646.1; NC_000921.1.
DR   AlphaFoldDB; Q9ZJA1; -.
DR   SMR; Q9ZJA1; -.
DR   STRING; 85963.jhp_1412; -.
DR   PRIDE; Q9ZJA1; -.
DR   EnsemblBacteria; AAD06990; AAD06990; jhp_1412.
DR   KEGG; hpj:jhp_1412; -.
DR   eggNOG; COG1200; Bacteria.
DR   OMA; CTIQEEN; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN           1..623
FT                   /note="ATP-dependent DNA helicase RecG"
FT                   /id="PRO_0000102144"
FT   DOMAIN          246..404
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          422..578
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           353..356
FT                   /note="DEQH box"
FT   BINDING         259..266
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   623 AA;  71439 MW;  7C2A45B2C6CA5B3B CRC64;
     MQETDDLLKT LNVKSLLEAL LVYTPKGYKD LSLLERFETG LSGVLEVGIL EKKNYAKVLK
     IFAYSKRFYK NLELVFFNHS AFYYNQFKTG ESLFIYGKLE QSSFNQAYII NTPKILTEFG
     KISLIFKKVK NHKKIQENLQ KLLSLENLKK EGVKENVARL LLEIFFPTPH FVKDFETNKN
     FPSQHLNALK YIEMLFYMKN LERKKLQFNA KIACPNNSER LKAFIASLPF KLTRDQQNAI
     KEIQSDLTSP IACKRLIIGD VGCGKTMVIL ASMVLAYPNK TLLMAPTSIL AKQLYHEALK
     FLPPYFEVEL LLGGSHKKRS NHLFEKITHV VIGTQALLFD KRDLNEFALV ITDEQHRFGT
     KQRYQLEKMA SSKGNKPHSL QFSATPIPRT LALAKSAFVK TTMIREIPYP KEIETLVLHK
     REFKIVMEKI SEEIAKNHQV IVVYPLVNKS EKIPYLSLSE GASFWQKRFK NIYTTSGQDK
     NKEEVIEEFR ELGSILLATT LIEVGISLPR LSVIVILAPE RLGLATLHQL RGRVSRNGLK
     GYCFLCTIQE ENERLEKFAD ELDGFKIAEL DLQYRKSGDL LQGGKQSGNS FEYIDLARDE
     NIIAEVKQDF LKNASVSQGT FEN