RECG_HELPY
ID RECG_HELPY Reviewed; 623 AA.
AC O26051;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=ATP-dependent DNA helicase RecG;
DE EC=3.6.4.12;
GN Name=recG; OrderedLocusNames=HP_1523;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC Holliday junction intermediates to mature products by catalyzing branch
CC migration. Has a DNA unwinding activity characteristic of a DNA
CC helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC DNA) (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000305}.
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DR EMBL; AE000511; AAD08562.1; -; Genomic_DNA.
DR PIR; C64710; C64710.
DR RefSeq; NP_208313.1; NC_000915.1.
DR RefSeq; WP_001158370.1; NC_018939.1.
DR AlphaFoldDB; O26051; -.
DR SMR; O26051; -.
DR DIP; DIP-3433N; -.
DR IntAct; O26051; 9.
DR MINT; O26051; -.
DR STRING; 85962.C694_07890; -.
DR PaxDb; O26051; -.
DR EnsemblBacteria; AAD08562; AAD08562; HP_1523.
DR KEGG; hpy:HP_1523; -.
DR PATRIC; fig|85962.47.peg.1637; -.
DR eggNOG; COG1200; Bacteria.
DR OMA; CTIQEEN; -.
DR PhylomeDB; O26051; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding;
KW Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..623
FT /note="ATP-dependent DNA helicase RecG"
FT /id="PRO_0000102143"
FT DOMAIN 246..404
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 422..578
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT MOTIF 353..356
FT /note="DEQH box"
FT BINDING 259..266
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 623 AA; 71393 MW; 5871C51978F065B4 CRC64;
MQETDNLLKT LNVKSLLEAL LVYTPKGYKD LNLLERFETG LSGVLEVGIL EKRNYAKVLK
IFAYSKRFYK NLELVFFNYS AFHHSQFKTG ESLFIYGKLE QSSFNQAYII NTPKIITKFG
KISLIFKKVK NHKKIQENLQ KLISLENLKK EGVKENIAHL LLEIFFPTPH FVKDFETNKN
FPSQHLNALK YIEMLFYMKN LERKKLQFGA KIACPNNNER LKAFIASLPF KLTRDQQNAI
KEIQNDLTSS IACKRLIIGD VGCGKTMVIL ASMVLTYPNK TLLMAPTSIL AKQLYNEALK
FLPPYFEVEL LLGGSYKKRS NHLFETITHV VIGTQALLFD KRDLNEFALV ITDEQHRFGT
KQRYQLEKMA SSKGNKPHSL QFSATPIPRT LALAKSAFVK TTMIREIPYP KEIETLVLHK
RDFKIVMEKI SEEIAKNHQV IVVYPLVNES EKIPYLSLSE GASFWQKRFK KVYTTSGQDK
NKEEVIEEFR ESGSILLATT LIEVGISLPR LSVMVILAPE RLGLATLHQL RGRVSRNGLK
GYCFLCTIQE ENERLEKFAD ELDGFKIAEL DLEYRKSGDL LQGGEQSGNS FEYIDLAKDE
NIIAEVKRDF LKAASVSRGT FEN
