ID   RECK8_HUMAN             Reviewed;         105 AA.
AC   P61575;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Endogenous retrovirus group K member 8 Rec protein;
DE   AltName: Full=HERV-K115 Rec protein;
DE   AltName: Full=HERV-K_8p23.1 provirus Rec protein;
GN   Name=ERVK-8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11591322; DOI=10.1016/s0960-9822(01)00455-9;
RA   Turner G., Barbulescu M., Su M., Jensen-Seaman M.I., Kidd K.K., Lenz J.;
RT   "Insertional polymorphisms of full-length endogenous retroviruses in
RT   humans.";
RL   Curr. Biol. 11:1531-1535(2001).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=15063128; DOI=10.1016/j.virol.2004.01.023;
RA   Mayer J., Ehlhardt S., Seifert M., Sauter M., Mueller-Lantzsch N.,
RA   Mehraein Y., Zang K.-D., Meese E.U.;
RT   "Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein
RT   coding capacity and transcriptional activity.";
RL   Virology 322:190-198(2004).
CC   -!- FUNCTION: Retroviral replication requires the nuclear export and
CC       translation of unspliced, singly-spliced and multiply-spliced
CC       derivatives of the initial genomic transcript. Rec interacts with a
CC       highly structured RNA element (RcRE) present in the viral 3'LTR and
CC       recruits the cellular nuclear export machinery. This permits export to
CC       the cytoplasm of unspliced genomic or incompletely spliced subgenomic
CC       viral transcripts (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms homodimers, homotrimers, and homotetramers via a C-
CC       terminal domain. Associates with XPO1 and with ZNF145 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm.
CC       When in the nucleus, resides in the nucleolus (By similarity).
CC       {ECO:0000250}.
CC   -!- MISCELLANEOUS: Despite functional similarity, Rec shares almost no
CC       sequence homology with HIV-1 Rev and HTLV-1 Rex.
CC   -!- MISCELLANEOUS: Insertional polymorphism. Provirus present in 16% of
CC       tested individuals.
CC   -!- MISCELLANEOUS: Has a type 2 genome. The HERV-K(HML-2) family contains
CC       type 1 and type 2 genomes depending on the absence or presence of 292
CC       nucleotides at the 5'-end of the env gene. Rec proteins are translated
CC       from a doubly spliced transcript expressed exclusively by HERV-K(HML-2)
CC       type 2 proviral genomes. The first exon comprises the 87 N-terminal
CC       amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second
CC       exon (18 amino acids) is positioned in the 3' part of the proviral
CC       genome.
CC   -!- MISCELLANEOUS: Intragenic, in first intron of DEFB107 gene.
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DR   EMBL; AY037929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P61575; -.
DR   SMR; P61575; -.
DR   BioMuta; HGNC:32302; -.
DR   MassIVE; P61575; -.
DR   PeptideAtlas; P61575; -.
DR   PRIDE; P61575; -.
DR   GeneCards; ERVK-8; -.
DR   HGNC; HGNC:32302; ERVK-8.
DR   neXtProt; NX_P61575; -.
DR   PhylomeDB; P61575; -.
DR   Pharos; P61575; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; ERV; mRNA transport; Nucleus; Reference proteome; RNA-binding;
KW   Transport; Transposable element.
FT   CHAIN           1..105
FT                   /note="Endogenous retrovirus group K member 8 Rec protein"
FT                   /id="PRO_0000186779"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           13..20
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           50..59
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        10..24
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   105 AA;  11844 MW;  9935AF37474B7C2F CRC64;
     MNPSEMQRKA PPRRRRHRNR APLTHKMNKM VTSEEQMKLP STKKAEPPTW AQLKKLTQLA
     TKYLENTKVT QTPESMLLAA LMIVSMVSAG VLNSSEETAT IENGP