RECN_MYCLE
ID RECN_MYCLE Reviewed; 587 AA.
AC Q49896; O08103;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=DNA repair protein RecN;
DE AltName: Full=Recombination protein N;
GN Name=recN; OrderedLocusNames=ML1360; ORFNames=MLC1351.12c;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Smith D.R., Robison K.;
RL Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: May be involved in recombinational repair of damaged DNA.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RecN family. {ECO:0000305}.
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DR EMBL; U00021; AAA50914.1; -; Genomic_DNA.
DR EMBL; Z95117; CAB08275.1; -; Genomic_DNA.
DR EMBL; AL583921; CAC31741.1; -; Genomic_DNA.
DR PIR; S72966; S72966.
DR RefSeq; NP_301970.1; NC_002677.1.
DR RefSeq; WP_010908291.1; NC_002677.1.
DR AlphaFoldDB; Q49896; -.
DR SMR; Q49896; -.
DR STRING; 272631.ML1360; -.
DR EnsemblBacteria; CAC31741; CAC31741; CAC31741.
DR KEGG; mle:ML1360; -.
DR PATRIC; fig|272631.5.peg.2517; -.
DR Leproma; ML1360; -.
DR eggNOG; COG0497; Bacteria.
DR HOGENOM; CLU_018297_3_0_11; -.
DR OMA; QVICVTH; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR004604; DNA_recomb/repair_RecN.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR PANTHER; PTHR11059; PTHR11059; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF003128; RecN; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00634; recN; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..587
FT /note="DNA repair protein RecN"
FT /id="PRO_0000188021"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 587 AA; 62724 MW; 58BC63F38A4DB732 CRC64;
MLTEIRIESL GAISVATAEF DRGLTVLTGE TGTGKTMVVT GLHLLGGARA DASRVRSGAN
RAVVEGRFTT TDLDDVVVAQ LDGILNASGS ERDEDGSVIV LRSVSRDGPS RSYLGGRSVP
AKSLGSFTTE LLALHGQNDQ LRLVRPEEQR AALDRYAAAG PSCERYRELR DAWLLARSDL
IDRRNRIREL VQEADRLKFA LSEIDSVDPQ PGEDNALVAD IVRLSELDML REVAVNARAA
LSGALDDMDV SGSNAVACMG QAKAALESTD DATLRAFADQ VGEVLTVVVE VGRELGEYLE
ELPVDASALE SKLVRQAELC TLTRKYAADI DGVLQWARES RERLEQLDVS YERLAGVESR
VDELERQLSQ AAVDLSKLRR DAANRLAKEV TAELSALAMV DAEFTISVTT DLIPLTDYKR
SAAVTLPSGG VARAGADGVD QVEFGFAAHR GMTVLPLAKS ASGGELSRVM LALEVVLATS
AAGTTMVFDE VDVGVGGRAA VQIGRRLARL ARTHQVIVVT HLPQVAAYAD VHLVVHSAGL
DGASDVRRLA GDDRVAELAR MLAGLGESDS GRAHARELLD AARKDKS