ID   RECN_MYCTU              Reviewed;         587 AA.
AC   P9WHI7; L0T7E7; O33197; P0A5U6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=DNA repair protein RecN;
DE   AltName: Full=Recombination protein N;
GN   Name=recN; OrderedLocusNames=Rv1696; ORFNames=MTCI125.18;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: May be involved in recombinational repair of damaged DNA.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RecN family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44461.1; -; Genomic_DNA.
DR   PIR; G70502; G70502.
DR   RefSeq; NP_216212.1; NC_000962.3.
DR   RefSeq; WP_003408385.1; NZ_NVQJ01000010.1.
DR   AlphaFoldDB; P9WHI7; -.
DR   SMR; P9WHI7; -.
DR   STRING; 83332.Rv1696; -.
DR   PaxDb; P9WHI7; -.
DR   DNASU; 885805; -.
DR   GeneID; 45425665; -.
DR   GeneID; 885805; -.
DR   KEGG; mtu:Rv1696; -.
DR   TubercuList; Rv1696; -.
DR   eggNOG; COG0497; Bacteria.
DR   OMA; QVICVTH; -.
DR   PhylomeDB; P9WHI7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0009314; P:response to radiation; IBA:GO_Central.
DR   GO; GO:0009432; P:SOS response; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR004604; DNA_recomb/repair_RecN.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   PANTHER; PTHR11059; PTHR11059; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   PIRSF; PIRSF003128; RecN; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00634; recN; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; DNA damage; DNA repair; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..587
FT                   /note="DNA repair protein RecN"
FT                   /id="PRO_0000188022"
FT   BINDING         29..36
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   587 AA;  62229 MW;  4B7051EFB60102E7 CRC64;
     MLTELRIESL GAISVATAEF DRGFTVLTGE TGTGKTMVVT GLHLLGGARA DATRVRSGAD
     RAVVEGRFTT TDLDDATVAG LQAVLDSSGA ERDEDGSVIA LRSISRDGPS RAYLGGRGVP
     AKSLSGFTNE LLTLHGQNDQ LRLMRPDEQR GALDRFAAAG EAVQRYRKLR DAWLTARRDL
     VDRRNRAREL AQEADRLKFA LNEIDTVDPQ PGEDVALVAD IARLSELDTL REAATTARAT
     LCGTPDADAF DRGAVDSLGR ARAALQSSDD AALRGLAEQV GEALTVVVDA VAELGAYLDE
     LPADASALDA KLARQAQLRT LTRKYAADID GVLRWADEAR ARLAQLDVSE EGLAALERRT
     GELAHELGQA AVDLSTIRRK AAKRLAKEVS AELSALAMAD AEFTIGVTTE LADHGDPVAL
     ALASGELARA GADGVDAVEF GFVAHRGMTV LPLAKSASGG ELSRVMLSLE VVLATSRKQA
     AGTTMVFDEI DAGVGGWAAV QIGRRLARLA RTHQVIVVTH LPQVAAYADV HLMVQRTGRD
     GASGVRRLTS EDRVAELARM LAGLGDSDSG RAHARELLET AQNDELT