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RECO_STRR6
ID   RECO_STRR6              Reviewed;         256 AA.
AC   Q8DRN4;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=DNA repair protein RecO {ECO:0000255|HAMAP-Rule:MF_00201};
DE   AltName: Full=Recombination protein O {ECO:0000255|HAMAP-Rule:MF_00201};
GN   Name=recO {ECO:0000255|HAMAP-Rule:MF_00201}; OrderedLocusNames=spr0036;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25569614; DOI=10.1371/journal.pgen.1004934;
RA   Johnston C., Mortier-Barriere I., Granadel C., Polard P., Martin B.,
RA   Claverys J.P.;
RT   "RecFOR is not required for pneumococcal transformation but together with
RT   XerS for resolution of chromosome dimers frequently formed in the
RT   process.";
RL   PLoS Genet. 11:E1004934-E1004934(2015).
CC   -!- FUNCTION: Involved in DNA repair and RecF pathway recombination (By
CC       similarity). Plays no role in chromosomal or plasmid transformation but
CC       is required for resolution of chromosome dimers occurring as
CC       intermediates in the formation of merodiploids by transformation
CC       (PubMed:25569614). {ECO:0000255|HAMAP-Rule:MF_00201,
CC       ECO:0000269|PubMed:25569614}.
CC   -!- DISRUPTION PHENOTYPE: Mutant is sensitive to the alkylating agent
CC       methyl methanesulfonate and the DNA cross-linking agent mitomycin C.
CC       {ECO:0000269|PubMed:25569614}.
CC   -!- SIMILARITY: Belongs to the RecO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00201}.
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DR   EMBL; AE007317; AAK98840.1; -; Genomic_DNA.
DR   PIR; D97876; D97876.
DR   RefSeq; NP_357630.1; NC_003098.1.
DR   RefSeq; WP_000616166.1; NC_003098.1.
DR   AlphaFoldDB; Q8DRN4; -.
DR   SMR; Q8DRN4; -.
DR   STRING; 171101.spr0036; -.
DR   PRIDE; Q8DRN4; -.
DR   EnsemblBacteria; AAK98840; AAK98840; spr0036.
DR   GeneID; 60233512; -.
DR   KEGG; spr:spr0036; -.
DR   PATRIC; fig|171101.6.peg.42; -.
DR   eggNOG; COG1381; Bacteria.
DR   HOGENOM; CLU_066632_4_0_9; -.
DR   OMA; CPQHYHE; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0043590; C:bacterial nucleoid; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006302; P:double-strand break repair; IBA:GO_Central.
DR   Gene3D; 1.20.1440.120; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_00201; RecO; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR022572; DNA_rep/recomb_RecO_N.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR003717; RecO.
DR   InterPro; IPR042242; RecO_C.
DR   PANTHER; PTHR33991; PTHR33991; 1.
DR   Pfam; PF02565; RecO_C; 1.
DR   Pfam; PF11967; RecO_N; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   TIGRFAMs; TIGR00613; reco; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Reference proteome.
FT   CHAIN           1..256
FT                   /note="DNA repair protein RecO"
FT                   /id="PRO_0000205010"
SQ   SEQUENCE   256 AA;  29818 MW;  8C445C3D1E677605 CRC64;
     MIQSITSQGL VLYNRNFRED DKLVKIFTEQ VGKRMFFVKH AGQSKLAPVI QPLVLARFLL
     RINDDGLSYI EDYHEVMTFP KINSDLFVMA YATYVAALAD ASLQDNQQDA PLFAFLQKTL
     ELMEAGLDYQ VLTNIFEIQI LTRFGISLNF NECVFCHRVG QAFDFSFKYG TCLCPEHYHE
     DERRCHLNPN IPYLLNQFQA IDFETLETIS LKPGIKQELR QFMDQLYEEY VGIHLKSKKF
     IDSLADWGQL LKEEKK
 
 
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