RECQ_SALTY
ID RECQ_SALTY Reviewed; 609 AA.
AC P40724; Q9L6N8;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=ATP-dependent DNA helicase RecQ;
DE EC=3.6.4.12;
GN Name=recQ; OrderedLocusNames=STM3958; ORFNames=STMD1.32;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
RX PubMed=8300539; DOI=10.1128/jb.176.3.861-870.1994;
RA Brok R.G.P.M., Brinkman E., van Boxtel R., Bekkers A.C.A.P., Verheij H.M.,
RA Tommassen J.;
RT "Molecular characterization of enterobacterial pldA genes encoding outer
RT membrane phospholipase A.";
RL J. Bacteriol. 176:861-870(1994).
CC -!- FUNCTION: Involved in the RecF recombination pathway; its gene
CC expression is under the regulation of the SOS system. It is a DNA
CC helicase.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF33434.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL22802.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF233324; AAF33434.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006468; AAL22802.1; ALT_INIT; Genomic_DNA.
DR EMBL; X76900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_462843.1; NC_003197.2.
DR AlphaFoldDB; P40724; -.
DR SMR; P40724; -.
DR STRING; 99287.STM3958; -.
DR PaxDb; P40724; -.
DR EnsemblBacteria; AAL22802; AAL22802; STM3958.
DR GeneID; 1255484; -.
DR KEGG; stm:STM3958; -.
DR PATRIC; fig|99287.12.peg.4176; -.
DR HOGENOM; CLU_001103_14_3_6; -.
DR PhylomeDB; P40724; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0043590; C:bacterial nucleoid; IBA:GO_Central.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030894; C:replisome; IBA:GO_Central.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.80; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; SSF47819; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR01389; recQ; 1.
DR TIGRFAMs; TIGR00614; recQ_fam; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding;
KW Helicase; Hydrolase; Nucleotide-binding; Reference proteome; SOS response.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..609
FT /note="ATP-dependent DNA helicase RecQ"
FT /id="PRO_0000205034"
FT DOMAIN 34..202
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 223..371
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT DOMAIN 529..609
FT /note="HRDC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00328"
FT MOTIF 146..149
FT /note="DEAH box"
FT BINDING 47..54
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 609 AA; 68321 MW; 7C2FAA79D25444ED CRC64;
MAQAEVLNLE SGAKQVLQET FGYQQFRPGQ EAIIDTALSG RDCLVVMPTG GGKSLCYQIP
ALLLDGLTVV VSPLISLMKD QVDQLLANGV AAACLNSTQS REQQLEVMAG CRTGQIRLLY
IAPERLMLDN FLDHLAHWNP VLLAVDEAHC ISQWGHDFRP EYAALGQLRQ RFPALPFMAL
TATADDTTRQ DIIRLLGLND PLIQISSFDR PNIRYMLMEK FKPLDQLMRY VQEQRGKSGI
IYCNSRAKVE DTAARLQSRG ISAAAYHAGL ENAIRVDVQE KFQRDDLQIV VATVAFGMGI
NKPNVRFVVH FDIPRNIESY YQETGRAGRD GLPAEAMLFY DPADMAWLRR CLEEKPAGQL
QDIERHKLNA MGAFAEAQTC RRLVLLNYFG EGRQEPCGNC DICLDPPKQY DGLNDAQIAL
STIGRVNQRF GMGYVVEVIR GANNQRIRDF GHDKLKVYGM GREKSHEHWV SVIRQLIHLG
LVMQNIAQHS ALQLTDAARP VLRGDVPLKL AVPRIVALKP RVMQKSFGGN YDRKLFAKLR
KLRKAIADEE NIPPYVVFND ATLIEMAEQM PVSASEMLSV NGVGMRKLER FGKEFMALIR
AHVDGDDEE
