ID   RECQ_SYNY3              Reviewed;         478 AA.
AC   P73421;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=ATP-dependent DNA helicase RecQ;
DE            EC=3.6.4.12;
GN   Name=recQ; OrderedLocusNames=slr1536;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: DNA helicase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BA000022; BAA17461.1; -; Genomic_DNA.
DR   PIR; S77358; S77358.
DR   AlphaFoldDB; P73421; -.
DR   SMR; P73421; -.
DR   IntAct; P73421; 3.
DR   STRING; 1148.1652540; -.
DR   PaxDb; P73421; -.
DR   EnsemblBacteria; BAA17461; BAA17461; BAA17461.
DR   KEGG; syn:slr1536; -.
DR   eggNOG; COG0514; Bacteria.
DR   InParanoid; P73421; -.
DR   OMA; CRWQFLL; -.
DR   PhylomeDB; P73421; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0043590; C:bacterial nucleoid; IBA:GO_Central.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030894; C:replisome; IBA:GO_Central.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR   GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032284; RecQ_Zn-bd.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF16124; RecQ_Zn_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00614; recQ_fam; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Helicase; Hydrolase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..478
FT                   /note="ATP-dependent DNA helicase RecQ"
FT                   /id="PRO_0000205038"
FT   DOMAIN          28..202
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          229..380
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           142..145
FT                   /note="DEAH box"
FT   BINDING         41..48
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   478 AA;  54787 MW;  DD0974C10E4E6924 CRC64;
     MADRQSLEEA LRRIWGYDHF RYPQGEVIDC LLARRDCLVV LPTGGGKSIC FQLPALLGEG
     LTLVVSPLVA LMEDQVQSLR RQNLPAACLH SQLSRPERKQ VLYQLGQQQL KLLYLSPETL
     LSEPVWNLLR QPQVKLQGIM LDEAHCLVQW GDSFRPAYRR LGALRRGLGR DKGQIPLAAF
     TATADRQQQN LIVEGLNLRS PECFQVSPHR PQLHLKVKMV LSEYCRRQQL RRFLLKHLQE
     SGLIYVRTRT MAINLAQWLQ ERGFDSEAYH GGLGPHQRRQ LEQKWLTGQI SSVVCTNAFG
     LGIDKPDTRW VLHYQAPLML MDYLQEVGRA GRDLQPAECL TLVSEPTGWL DSGDRQLRQY
     FLSQASKYLQ RAEVLSQQIP SQGNLGQLKA HFPDLEMALA WLHRRGNLEW LDPFNYRINP
     GHYQANPLEE LKSQYRLMTQ YLTTSRCRWQ TILVAFGDNS PAARRPCGTC DNCLVGRC