ID   RECR_STRR6              Reviewed;         198 AA.
AC   P0A454; Q9ZHC4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Recombination protein RecR {ECO:0000255|HAMAP-Rule:MF_00017};
GN   Name=recR {ECO:0000255|HAMAP-Rule:MF_00017}; Synonyms=recM;
GN   OrderedLocusNames=spr1516;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25569614; DOI=10.1371/journal.pgen.1004934;
RA   Johnston C., Mortier-Barriere I., Granadel C., Polard P., Martin B.,
RA   Claverys J.P.;
RT   "RecFOR is not required for pneumococcal transformation but together with
RT   XerS for resolution of chromosome dimers frequently formed in the
RT   process.";
RL   PLoS Genet. 11:E1004934-E1004934(2015).
CC   -!- FUNCTION: May play a role in DNA repair. It seems to be involved in an
CC       RecBC-independent recombinational process of DNA repair. It may act
CC       with RecF and RecO (By similarity). Plays no role in chromosomal or
CC       plasmid transformation but is required for resolution of chromosome
CC       dimers occurring as intermediates in the formation of merodiploids by
CC       transformation (PubMed:25569614). {ECO:0000255|HAMAP-Rule:MF_00017,
CC       ECO:0000269|PubMed:25569614}.
CC   -!- DISRUPTION PHENOTYPE: Mutant is sensitive to the alkylating agent
CC       methyl methanesulfonate and the DNA cross-linking agent mitomycin C.
CC       {ECO:0000269|PubMed:25569614}.
CC   -!- SIMILARITY: Belongs to the RecR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00017}.
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DR   EMBL; AE007317; AAL00320.1; -; Genomic_DNA.
DR   PIR; C98061; C98061.
DR   RefSeq; NP_359109.1; NC_003098.1.
DR   RefSeq; WP_000966743.1; NC_003098.1.
DR   AlphaFoldDB; P0A454; -.
DR   SMR; P0A454; -.
DR   STRING; 171101.spr1516; -.
DR   EnsemblBacteria; AAL00320; AAL00320; spr1516.
DR   GeneID; 60234357; -.
DR   KEGG; spr:spr1516; -.
DR   PATRIC; fig|171101.6.peg.1636; -.
DR   eggNOG; COG0353; Bacteria.
DR   HOGENOM; CLU_060739_1_0_9; -.
DR   OMA; DVMAIEN; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   CDD; cd01025; TOPRIM_recR; 1.
DR   HAMAP; MF_00017; RecR; 1.
DR   InterPro; IPR000093; DNA_Rcmb_RecR.
DR   InterPro; IPR023627; Rcmb_RecR.
DR   InterPro; IPR023628; Rcmb_RecR_C4-type_Zn.
DR   InterPro; IPR015967; Rcmb_RecR_CS.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR034137; TOPRIM_RecR.
DR   PANTHER; PTHR30446; PTHR30446; 1.
DR   Pfam; PF02132; RecR; 1.
DR   Pfam; PF13662; Toprim_4; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF111304; SSF111304; 1.
DR   TIGRFAMs; TIGR00615; recR; 1.
DR   PROSITE; PS01300; RECR; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; Metal-binding;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..198
FT                   /note="Recombination protein RecR"
FT                   /id="PRO_0000190399"
FT   DOMAIN          80..175
FT                   /note="Toprim"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00017"
FT   ZN_FING         57..72
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00017"
SQ   SEQUENCE   198 AA;  21689 MW;  FC6F0E98E3933752 CRC64;
     MLYPTPIAKL IDSYSKLPGI GIKTATRLAF YTIGMSADDV NEFAKNLLSA KRELTYCSIC
     GRLTDDDPCS ICTDPTRDQT TILVLEDSRD VAAMENIQEY HGLYHVLHGL ISPMNGISPD
     DINLKSLMTR LMDSEVSEVI VATNATADGE ATSMYLSRLL KPAGIKVTRL ARGLAVGADI
     EYADEVTLLR AIENRTEL