ID   RECX_ECO57              Reviewed;         166 AA.
AC   P66000; P59208; Q8X875;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Regulatory protein RecX;
GN   Name=recX; OrderedLocusNames=Z4001, ECs3555;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Modulates RecA activity through direct physical interaction.
CC       Can inhibit both RecA recombinase and coprotease activities. May have a
CC       regulatory role during the SOS response. Inhibits DNA strand exchange
CC       in vitro (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RecX family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57803.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36978.1; -; Genomic_DNA.
DR   PIR; C91073; C91073.
DR   PIR; G85917; G85917.
DR   RefSeq; NP_311582.1; NC_002695.1.
DR   RefSeq; WP_000140506.1; NZ_SWKA01000005.1.
DR   PDB; 3C1D; X-ray; 1.80 A; A/B=9-166.
DR   PDBsum; 3C1D; -.
DR   AlphaFoldDB; P66000; -.
DR   SMR; P66000; -.
DR   STRING; 155864.EDL933_3862; -.
DR   EnsemblBacteria; AAG57803; AAG57803; Z4001.
DR   EnsemblBacteria; BAB36978; BAB36978; ECs_3555.
DR   GeneID; 66673433; -.
DR   GeneID; 914723; -.
DR   KEGG; ece:Z4001; -.
DR   KEGG; ecs:ECs_3555; -.
DR   PATRIC; fig|386585.9.peg.3713; -.
DR   eggNOG; COG2137; Bacteria.
DR   HOGENOM; CLU_066607_3_2_6; -.
DR   OMA; RCKMQEK; -.
DR   EvolutionaryTrace; P66000; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006282; P:regulation of DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 3.
DR   HAMAP; MF_01114; RecX; 1.
DR   InterPro; IPR003783; Regulatory_RecX.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR33602; PTHR33602; 1.
DR   Pfam; PF02631; RecX; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA damage; DNA repair; Reference proteome;
KW   SOS response.
FT   CHAIN           1..166
FT                   /note="Regulatory protein RecX"
FT                   /id="PRO_0000162431"
FT   HELIX           9..22
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           29..37
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   STRAND          40..42
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   STRAND          45..47
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           53..65
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           71..84
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           89..98
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           103..113
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           117..129
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           137..149
FT                   /evidence="ECO:0007829|PDB:3C1D"
FT   HELIX           154..157
FT                   /evidence="ECO:0007829|PDB:3C1D"
SQ   SEQUENCE   166 AA;  19410 MW;  E22E4AED81712E63 CRC64;
     MTESTSRRPA YARLLDRAVR ILAVRDHSEQ ELRRKLAAPI MGKNGPEEID ATAEDYERVI
     AWCHEHGYLD DSRFVARFIA SRSRKGYGPA RIRQELNQKG ISREATEKAM RECDIDWCAL
     ARDQATRKYG EPLPTVFSEK VKIQRFLLYR GYLMEDIQDI WRNFAD