RECX_ECOL6
ID RECX_ECOL6 Reviewed; 166 AA.
AC P65999; P59208; Q8X875;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Regulatory protein RecX;
GN Name=recX; OrderedLocusNames=c3252;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Modulates RecA activity through direct physical interaction.
CC Can inhibit both RecA recombinase and coprotease activities. May have a
CC regulatory role during the SOS response. Inhibits DNA strand exchange
CC in vitro (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RecX family. {ECO:0000305}.
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DR EMBL; AE014075; AAN81703.1; -; Genomic_DNA.
DR RefSeq; WP_000140506.1; NC_004431.1.
DR AlphaFoldDB; P65999; -.
DR SMR; P65999; -.
DR STRING; 199310.c3252; -.
DR EnsemblBacteria; AAN81703; AAN81703; c3252.
DR GeneID; 66673433; -.
DR KEGG; ecc:c3252; -.
DR eggNOG; COG2137; Bacteria.
DR HOGENOM; CLU_066607_3_2_6; -.
DR OMA; RCKMQEK; -.
DR BioCyc; ECOL199310:C3252-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006282; P:regulation of DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 3.
DR HAMAP; MF_01114; RecX; 1.
DR InterPro; IPR003783; Regulatory_RecX.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR33602; PTHR33602; 1.
DR Pfam; PF02631; RecX; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; SOS response.
FT CHAIN 1..166
FT /note="Regulatory protein RecX"
FT /id="PRO_0000162430"
SQ SEQUENCE 166 AA; 19410 MW; E22E4AED81712E63 CRC64;
MTESTSRRPA YARLLDRAVR ILAVRDHSEQ ELRRKLAAPI MGKNGPEEID ATAEDYERVI
AWCHEHGYLD DSRFVARFIA SRSRKGYGPA RIRQELNQKG ISREATEKAM RECDIDWCAL
ARDQATRKYG EPLPTVFSEK VKIQRFLLYR GYLMEDIQDI WRNFAD