ID   RECX_MYCTO              Reviewed;         174 AA.
AC   P9WHI0; L0TC39; O33280; P0A5U8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Regulatory protein RecX;
GN   Name=recX; OrderedLocusNames=MT2805;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Binds to RecA inhibiting ATP hydrolysis and the generation of
CC       heteroduplex DNA. It might act as an anti-recombinase to quell
CC       inappropriate recombinational repair during normal DNA metabolism. It
CC       is essential for cell survival (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RecX family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK47126.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK47126.1; ALT_INIT; Genomic_DNA.
DR   PIR; G70877; G70877.
DR   RefSeq; WP_003900562.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WHI0; -.
DR   SMR; P9WHI0; -.
DR   EnsemblBacteria; AAK47126; AAK47126; MT2805.
DR   KEGG; mtc:MT2805; -.
DR   PATRIC; fig|83331.31.peg.3023; -.
DR   HOGENOM; CLU_066607_0_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006282; P:regulation of DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 2.
DR   HAMAP; MF_01114; RecX; 1.
DR   InterPro; IPR003783; Regulatory_RecX.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR33602; PTHR33602; 1.
DR   Pfam; PF02631; RecX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..174
FT                   /note="Regulatory protein RecX"
FT                   /id="PRO_0000428183"
SQ   SEQUENCE   174 AA;  19146 MW;  029D7FA766488328 CRC64;
     MTVSCPPPST SEREEQARAL CLRLLTARSR TRAELAGQLA KRGYPEDIGN RVLDRLAAVG
     LVDDTDFAEQ WVQSRRANAA KSKRALAAEL HAKGVDDDVI TTVLGGIDAG AERGRAEKLV
     RARLRREVLI DDGTDEARVS RRLVAMLARR GYGQTLACEV VIAELAAERE RRRV