ID   RECX_MYCTU              Reviewed;         174 AA.
AC   P9WHI1; L0TC39; O33280; P0A5U8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Regulatory protein RecX;
GN   Name=recX; OrderedLocusNames=Rv2736c; ORFNames=MTV002.01c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-10, AND FUNCTION.
RX   PubMed=12218174; DOI=10.1073/pnas.192178999;
RA   Venkatesh R., Ganesh N., Guhan N., Reddy M.S., Chandrasekhar T.,
RA   Muniyappa K.;
RT   "RecX protein abrogates ATP hydrolysis and strand exchange promoted by
RT   RecA: insights into negative regulation of homologous recombination.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12091-12096(2002).
CC   -!- FUNCTION: Binds to RecA inhibiting ATP hydrolysis and the generation of
CC       heteroduplex DNA. It might act as an anti-recombinase to quell
CC       inappropriate recombinational repair during normal DNA metabolism. It
CC       is essential for cell survival. {ECO:0000269|PubMed:12218174}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RecX family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45534.1; -; Genomic_DNA.
DR   PIR; G70877; G70877.
DR   RefSeq; NP_217252.1; NC_000962.3.
DR   RefSeq; WP_003900562.1; NZ_NVQJ01000017.1.
DR   AlphaFoldDB; P9WHI1; -.
DR   SMR; P9WHI1; -.
DR   STRING; 83332.Rv2736c; -.
DR   PaxDb; P9WHI1; -.
DR   GeneID; 888393; -.
DR   KEGG; mtu:Rv2736c; -.
DR   TubercuList; Rv2736c; -.
DR   eggNOG; COG2137; Bacteria.
DR   OMA; WVHSRHT; -.
DR   PhylomeDB; P9WHI1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0006282; P:regulation of DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 2.
DR   HAMAP; MF_01114; RecX; 1.
DR   InterPro; IPR003783; Regulatory_RecX.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR33602; PTHR33602; 1.
DR   Pfam; PF02631; RecX; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Reference proteome.
FT   CHAIN           1..174
FT                   /note="Regulatory protein RecX"
FT                   /id="PRO_0000162450"
SQ   SEQUENCE   174 AA;  19146 MW;  029D7FA766488328 CRC64;
     MTVSCPPPST SEREEQARAL CLRLLTARSR TRAELAGQLA KRGYPEDIGN RVLDRLAAVG
     LVDDTDFAEQ WVQSRRANAA KSKRALAAEL HAKGVDDDVI TTVLGGIDAG AERGRAEKLV
     RARLRREVLI DDGTDEARVS RRLVAMLARR GYGQTLACEV VIAELAAERE RRRV