ID   RECX_SHIFL              Reviewed;         166 AA.
AC   P66001; P59208; Q8X875;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Regulatory protein RecX;
GN   Name=recX; OrderedLocusNames=SF2721, S2912;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Modulates RecA activity through direct physical interaction.
CC       Can inhibit both RecA recombinase and coprotease activities. May have a
CC       regulatory role during the SOS response. Inhibits DNA strand exchange
CC       in vitro (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RecX family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN44213.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18039.1; -; Genomic_DNA.
DR   RefSeq; NP_708506.1; NC_004337.2.
DR   RefSeq; WP_000140506.1; NZ_WPGW01000014.1.
DR   AlphaFoldDB; P66001; -.
DR   SMR; P66001; -.
DR   STRING; 198214.SF2721; -.
DR   DNASU; 1079177; -.
DR   EnsemblBacteria; AAN44213; AAN44213; SF2721.
DR   EnsemblBacteria; AAP18039; AAP18039; S2912.
DR   GeneID; 1025697; -.
DR   GeneID; 66673433; -.
DR   KEGG; sfl:SF2721; -.
DR   KEGG; sfx:S2912; -.
DR   PATRIC; fig|198214.7.peg.3241; -.
DR   HOGENOM; CLU_066607_3_2_6; -.
DR   OMA; RCKMQEK; -.
DR   OrthoDB; 2025178at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006282; P:regulation of DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 3.
DR   HAMAP; MF_01114; RecX; 1.
DR   InterPro; IPR003783; Regulatory_RecX.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR33602; PTHR33602; 1.
DR   Pfam; PF02631; RecX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Reference proteome; SOS response.
FT   CHAIN           1..166
FT                   /note="Regulatory protein RecX"
FT                   /id="PRO_0000162468"
SQ   SEQUENCE   166 AA;  19410 MW;  E22E4AED81712E63 CRC64;
     MTESTSRRPA YARLLDRAVR ILAVRDHSEQ ELRRKLAAPI MGKNGPEEID ATAEDYERVI
     AWCHEHGYLD DSRFVARFIA SRSRKGYGPA RIRQELNQKG ISREATEKAM RECDIDWCAL
     ARDQATRKYG EPLPTVFSEK VKIQRFLLYR GYLMEDIQDI WRNFAD