ID   REDD_STRCO              Reviewed;         350 AA.
AC   P16922;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Transcriptional regulator RedD;
GN   Name=redD; OrderedLocusNames=SCO5877; ORFNames=SC2E9.18;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=2294088; DOI=10.1128/jb.172.1.326-333.1990;
RA   Narva K.E., Feitelson J.S.;
RT   "Nucleotide sequence and transcriptional analysis of the redD locus of
RT   Streptomyces coelicolor A3(2).";
RL   J. Bacteriol. 172:326-333(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: The RedD protein is probably one of several delicately
CC       balanced regulatory factors that contribute to the control of the
CC       biosynthesis of the antibiotic undecylprodigiosin (Red) in
CC       S.coelicolor.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M29790; AAA88556.1; -; Genomic_DNA.
DR   EMBL; AL939125; CAA16486.1; -; Genomic_DNA.
DR   PIR; T34829; T34829.
DR   RefSeq; NP_629999.1; NC_003888.3.
DR   RefSeq; WP_011030508.1; NZ_VNID01000007.1.
DR   AlphaFoldDB; P16922; -.
DR   SMR; P16922; -.
DR   STRING; 100226.SCO5877; -.
DR   PRIDE; P16922; -.
DR   GeneID; 1101319; -.
DR   KEGG; sco:SCO5877; -.
DR   PATRIC; fig|100226.15.peg.5976; -.
DR   eggNOG; COG3629; Bacteria.
DR   HOGENOM; CLU_004665_0_1_11; -.
DR   InParanoid; P16922; -.
DR   OMA; SAWMIRT; -.
DR   PhylomeDB; P16922; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IDA:CACAO.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..350
FT                   /note="Transcriptional regulator RedD"
FT                   /id="PRO_0000110007"
FT   DNA_BIND        69..174
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   350 AA;  37796 MW;  573C96C2203EFBBB CRC64;
     MTGGGVLATM DPVRKLVRSQ PKIGRHPVAA GQDGRDRHPI RSWECGERAR TARTGRTVGR
     AADPSDHGPS LYNFGGCVEI NILGPVSIDT SHSGGGIRAG KVRTLVATLA IDAGRAVSLA
     DLVDELWGAT PPDNVLNALQ AHAARARKVL NERACPERAG GILRSVLGGY LLEIDPQCVD
     GNRFLRLVSQ GAALLPADPT RAVELLETGL RLWRGPALID AGEGRRCRGA AALFEERRLT
     ALEDLISAMF LRGGEAQAIA MLQQLVAQYP LRERFCELLM VGLYRVGRQG DALESYRLAR
     KRLDDELGVQ PGALLRRRHA EILAQDPVLK VPSALWREPY APADTSLLSA